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Total Knee Arthroplasty clinical trials

View clinical trials related to Total Knee Arthroplasty.

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NCT ID: NCT04423276 Recruiting - Clinical trials for Total Knee Arthroplasty

Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction

Start date: June 14, 2020
Phase: Phase 4
Study type: Interventional

Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase inhibitor can prevent the POCD after isoflurane anesthesia in aged mice. Donepezil is a commercial medicine used for the Alzheimer Disease, which is tolerable and has minimal adverse events. In present study a multi-center randomized case control study was conducted and we hypothesized that donepezil attenuate the POCD.

NCT ID: NCT04400708 Completed - Clinical trials for Total Knee Arthroplasty

Single-injection Adductor Canal Block for Total Knee Arthroplasty Under Spinal Anesthesia

Start date: May 28, 2020
Phase: N/A
Study type: Interventional

This study evaluates the effect of the single-injection adductor canal block in patients receiving total knee arthroplasty under spinal anesthesia.

NCT ID: NCT04366336 Withdrawn - Clinical trials for Total Knee Arthroplasty

BFRT vs Standard PT After Total Knee Arthroplasty

BFRT-TKA
Start date: February 18, 2021
Phase: N/A
Study type: Interventional

Background Blood flow restriction training (BFRT) uses a specialized tourniquet system to restrict arterial inflow and venous outflow to the limb during low-load resistance exercise. BFRT has the potential to augment strength gains for rehabilitation patients who are unable to tolerate high intensity resistance training. Objective To determine if BFRT will accelerate the recovery of thigh muscle function and strength in post-operative TKA compared to a standard post-operative rehabilitation protocol. Primary Outcome Measures: Quadriceps Strength: dynamometry (hand held) Secondary Outcomes Measures: Patient Reported Outcomes Knee Injury and Osteoarthritis Outcome Score, Jr Veterans Rand -12 Functional Measures Timed stair ascent Four square Test 5x Sit to Stand Test Study Design Open label randomized clinical trial with a 1:1 allocation in random sized blocks Sample Size Based on a Pre-TKA Quadriceps Maximal Voluntary Isometric Contraction mean of 18 with a standard deviation of 8, expecting a 20% improvement of MVIC with BFRT compared to standard Physical Therapy, with an α of 0.05 and β of 0.20 (80% power), the sample size is 63 in each arm. To account for a 20% drop-out rate, a total of 75 subjects will be enrolled in each arm Study Arms Control arm: Subjects will receive American College of Sports Medicine guided-strength training Experimental: Subjects will receive BFRT strength training as part of their post-operative physical therapy program for two months during normal post-op rehab.

NCT ID: NCT04347343 Completed - Clinical trials for Total Knee Arthroplasty

Combined NMES and BFR Training After TKA

COMBO
Start date: November 22, 2019
Phase: N/A
Study type: Interventional

The purpose of this feasibility study is to determine the initial efficacy of early combined Neuromuscular Electrical Stimulation (NMES) and Blood Flow Restriction (BFR) in addition to standard rehabilitation in 15 subjects after Total Knee Arthroplasty (TKA). The second aim is to determine the feasibility and patient perceptions of combined NMES and BFR by assessing: 1) adherence, 2) satisfaction and 3) safety.

NCT ID: NCT04341948 Active, not recruiting - Postoperative Pain Clinical Trials

Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System

Start date: August 6, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to gather information about how knee pain changes when small amounts of electricity are delivered to the nerves in the leg. This study will involve the use of a Peripheral Nerve Stimulation (PNS) System that is made by SPR Therapeutics (the sponsor of the study). The SPRINT PNS System was cleared by the FDA for up to 60 days of use in the back and/or extremities for the management of acute and chronic pain.

NCT ID: NCT04321356 Completed - Knee Osteoarthritis Clinical Trials

Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)

Start date: February 24, 2020
Phase:
Study type: Observational

The purpose of the study is to acquire kinematic in vivo fluoroscopy data from subjects who were implanted with Stryker Posterior Cruciate Retaining (PCR) , Stryker Posterior Stabilized (PS), Zimmer PCR, and Zimmer PS Total Knee Arthroplasty (TKAs). Our lab has previously collected data for the Smith & Nephew PCR, bi-cruciate retaining (BCR), and bi-cruciate stabilized (BCS) TKA.

NCT ID: NCT04308798 Recruiting - Clinical trials for Total Knee Arthroplasty

Comparison of Surgical Glove Contamination During Total Knee Arthroplasty Procedure : a Randomized Controlled Trial

Start date: July 2020
Phase: Phase 3
Study type: Interventional

Total knee arthroplasty post-op surgical site infection rate about 0.5- 5% Pre-operative , perioperative and post-operative prevention are importance for reduce surgical site infection The prevention of surgical-site infections (SSIs) is an integral component of nosocomial infection control and a major priority in orthopedic surgery. Surgical wound contamination must be prevented to avoid patient colonisation by microorganisms during surgery. Surgical glove changing perioperative can reduce contamination and perforation rate Orthopedic surgery had found contamination rate about 20-28 % Joint replacement procedure found contamination rate about 38-67% of all orthopedic surgery 12% of gloves are contaminated after draping and 24% once patient installation is complete. We hypothesis that changing surgical glove during total knee arthroplasty can reduce contamination rate on surgical glove.

NCT ID: NCT04258917 Withdrawn - Clinical trials for Total Knee Arthroplasty

Impact of Crutch Type on Gait and Functional Outcomes Post-knee Surgery

Start date: January 8, 2021
Phase: N/A
Study type: Interventional

Study withdrawn

NCT ID: NCT04164927 Completed - Exercise Clinical Trials

The Effects of Manual Lymphatic Drainage and Kinesiotaping on Lower Extremity Edema

Start date: January 1, 2015
Phase: N/A
Study type: Interventional

Significant trauma and muscular tightness often result during Total Knee Arthroplasty (TKA) surgery and thus act to restrict tissue fluid movement resulting with lower extremity edema. Kinesio Taping® is applied directly on the skin for restoration of normal fluid perfusion, removing congestion of lymphatic fluid or hemorrhages. In addition Manual Lymphatic Drainage (MLD) enhances blood circulation and stimulates the lymphatic movement and unblocks lymphatic territories. The aim of the study was to investigate the effectiveness of Kinesio Taping® and MLD in reducing postoperative edema and pain in the early stage after TKA.

NCT ID: NCT04163445 Recruiting - Knee Osteoarthritis Clinical Trials

Comparison of TKAs Using Force Plate Analysis

Start date: November 11, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate performance of two modern total knee arthroplasty designs using patient reported outcomes and force exhibited during various activities of daily living.