Hypothalamus-Pituitary-Adrenal Axis Assessement Clinical Trial
Official title:
Low Dose (1mcg) ACTH Stimulation Test for Assessment of the Hypothalamo-Pituitary- Adrenal Axis in Patients Treated With Topical Corticosteroids
The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.
Adrenocortical suppression is a potential complication of systemic corticosteroid treatement
but also of non systemic therapy like topical therapy.
The normalcy of hypothalamic-pituitary-adrenal axis ( HPA axis) of patients with chronic
skin diseases like atopic dermatitis, pemphigus or psoriasis which are treated with topical
steroids, will be assessed with the low dose (1mcg) adrenocortocotropin ( ACTH) stimulation
test. During this test serum cortisol levels are measured before, 30 and 60 mn after
intravenous administration of 1mcg of ACTH (synacthen).The results will be compared with age
and sex matched subjects with normal HPA axis as assessed by low dose ACTH stimulation test.
;
Observational Model: Case Control, Primary Purpose: Screening, Time Perspective: Cross-Sectional