Hyaluronic Acid Effect on Xenogenic Bone Healing

Tooth Loss Clinical Trial

Official title:

Hyaluronic Acid Effect on Xenogenic Bone Substitutes Healing During Ridge Preservations: A Radiological and Histomorphometric Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04377256
• Other study ID #: USJ-2019-267
• Status: Recruiting
• Phase: Phase 4
• Start date: May 1, 2020
• Est. completion date: May 10, 2021

Study information

• Verified date: May 2020
• Source: Saint-Joseph University
• Contact: Bachar A Husseini, DDS
• Phone: +96181483610
• Email: basharhusseini[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation.

Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 5
• Est. completion date: May 10, 2021
• Est. primary completion date: January 10, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients in need of tooth extraction and willing to receive dental implants in the extraction site

• Presence of two mono radicular teeth in need of extraction

Exclusion Criteria:

• Patients with systemic diseases

• Patients under 8 years and above 60 years.

• Presence of endodontic or periodontal lesion in the extraction sites

Related Conditions & MeSH terms

• Bone Resorption
• Tooth Loss

Intervention

Procedure:
• Ridge preservation: Tooth extration and immediat bone grafting in the socket
Following the tooth extraction, the socket is filled with a mixture of xenogenic bone and hyaluronic acid and sealed with an epithelio-connective arrested from the maxillary palate

Locations

Country	Name	City	State
Lebanon	Saint-Joseph university	Beirut
Lebanon	Universte Saint Joseph-Beyrouth	Beirut

Sponsors (1)

Lead Sponsor	Collaborator
Saint-Joseph University

Country where clinical trial is conducted

Lebanon, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Radiological assessement of the boe resorption	the baseline if the CBCT is compared to the 4 months post-op to assess the bone resorption	4 months
Primary	Histomorphometric analysis	During implant placement, a bone biopsy is harvested and stained with different colorants to assess microscopically the biological healing	4 months