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NCT03311919 Clinical Trial

Exploratory Study of "Natural Killer" Inflammatory Lymphocytes in Waste Per-operating of Tonsillectomy

Tonsillectomy Clinical Trial

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Official title:
Exploratory Study of "Natural Killer" Inflammatory Lymphocytes in Waste Per-operating of Tonsillectomy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03311919
Other study ID # P/2013/204
Secondary ID
Status Completed
Phase N/A
First received September 27, 2017
Last updated October 16, 2017
Start date January 2014
Est. completion date December 31, 2014

Study information
Verified date September 2017
Source Centre Hospitalier Universitaire de Besancon
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this study is to describe the frequency of the presence of cells Natural Killer (NK) expressing CD86 and HLA - DR in tonsils

Recruitment information / eligibility
Status Completed
Enrollment 11
Est. completion date December 31, 2014
Est. primary completion date May 2014
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- patient with programmed tonsillectomy as part of the care

Exclusion Criteria:

- patient opposition to use its waste of per-operating tonsillectomy for research purposes

- patient with immunosuppressive and/or corticoid treatment (> 1 mg/kg)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Besancon

References & Publications (1)

Loyon R, Picard E, Mauvais O, Queiroz L, Mougey V, Pallandre JR, Galaine J, Mercier-Letondal P, Kellerman G, Chaput N, Wijdenes J, Adotévi O, Ferrand C, Romero P, Godet Y, Borg C. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner. J Immunol. 2016 Jul 1;197(1):85-96. doi: 10.4049/jimmunol.1501147. Epub 2016 May 27. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary presence of lymphocytes NK expressing CD86 and HLA - DR by immunostaining and detection by flow cytometry inclusion
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