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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02859090
Other study ID # DUVILLARD UB 2012
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date August 26, 2014
Est. completion date November 20, 2014

Study information

Verified date January 2019
Source Centre Hospitalier Universitaire Dijon
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

It has recently been shown that various HSPs are strongly expressed in B lymphomas. Indeed, HSP90 stabilizes the protein Bcl-6 in diffuse large-cell B lymphomas. Pharmacological inhibition of HSP90 in vitro induced apoptosis in lymphoma cells (Cerchietti et al. Nat. Medicine, 2009, 1369-1376). In addition, HSP110 is strongly expressed in non-Hodgkin lymphomas, and targeting this HSP at the cell surface using specific antibodies could constitute a future therapy (Zappasodi et al. Blood, 2011, 4421-4430). Despite the importance of these proteins in the development of lymphomas, their expression and their role in the activation of normal B lymphocytes and the normal development of germinal centres is not known.

The expression of Heat shock proteins should vary among the different B lymphocyte populations present in the tonsils (naïve B cells, memory B cells, germinal centre B cells).

The aim of this study is to establish an expression profile for heat shock proteins in populations of B lymphocytes in human tonsils


Recruitment information / eligibility

Status Completed
Enrollment 5
Est. completion date November 20, 2014
Est. primary completion date November 20, 2014
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Persons who have provided oral consent

- Tonsillectomy in children or adults

Exclusion Criteria:

- Persons without national health insurance cover

- Adults under guardianship

- Pregnant or breast-feeding women

- Persons with positive HIV or HCV serology

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
tonsillectomy

Biological:
blood sample


Locations

Country Name City State
France CHU Dijon Bourgogne Dijon

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary expression of heat shock proteins Day one
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