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Tonsillectomy clinical trials

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NCT ID: NCT03420638 Recruiting - Tonsillectomy Clinical Trials

EXPAREL Post-tonsillectomy Clinical Trial

EXPCT
Start date: February 15, 2018
Phase: Phase 4
Study type: Interventional

Tonsillectomy is one of the most commonly performed surgical procedures in the United States. The primary indications for tonsillectomy in the adult population include recurrent pharyngitis, chronic tonsillitis, and obstructive pathology. Tonsillectomy is often associated with severe postoperative pain, which can result in prolonged poor oral intake, dehydration, and the need for high dose narcotics. In severely dehydrated patients, epithelial shedding and necrosis of soft tissues at the surgical site can lead to postoperative complications such as bleeding, delayed healing, and severe pain. The goal for this study is to explore the use of a long acting local anesthetic bupivacaine liposome injectable suspension (Exparel) to manage pain experienced by adult patients after tonsillectomy

NCT ID: NCT03352115 Not yet recruiting - Tonsillectomy Clinical Trials

Postoperative Oral Corticosteroids Following Tonsillectomy

Start date: January 2018
Phase: N/A
Study type: Interventional

Tonsillectomy is one of the most common surgical procedures in the United States, and post-operative pain management is a challenge for otolaryngologists. A 2013 black-box warning on codeine following tonsillectomy has drawn attention to potential concerns with all narcotics in these patients, and many surgeons try to avoid narcotics. The use of intra-operative corticosteroids has been proven to be beneficial in reducing post-operative morbidity, and some small studies have shown possible benefit to the use of post-operative oral corticosteroids as well, although the results of these studies are mixed. To date, no one has looked at whether the use of post-operative oral steroids may reduce or eliminate the need for narcotics. We aim to determine whether the addition of oral steroids to our post-operative pain regimen can reduce the need for narcotic pain medications.

NCT ID: NCT03311919 Completed - Tonsillectomy Clinical Trials

Exploratory Study of "Natural Killer" Inflammatory Lymphocytes in Waste Per-operating of Tonsillectomy

LINK
Start date: January 2014
Phase: N/A
Study type: Observational

The aim of this study is to describe the frequency of the presence of cells Natural Killer (NK) expressing CD86 and HLA - DR in tonsils

NCT ID: NCT03266094 Completed - Tonsillectomy Clinical Trials

A Study of BiZactâ„¢ on Children and Adolescents Undergoing Tonsillectomy

Start date: September 30, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to assess safety and performance with the use of the BiZactâ„¢ device in tonsillectomy procedures in children and adolescents.

NCT ID: NCT03239743 Recruiting - Tonsillectomy Clinical Trials

Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents

Start date: July 20, 2017
Phase: N/A
Study type: Interventional

Pain and anxiety have a direct correlation. Patients who experience anxiety are more susceptible to feeling pain, and patients who experience pain are more likely to have a component of anxiety associated with their pain. A common technique used by pain psychologists to help minimize pain is distraction. Different forms of distraction include video games, movies, music, etc. Recently, doctors and researchers around the world have begun experimenting with Virtual Reality as a distraction technique. A review of the use of virtual reality compared to the current standard of care may help uncover important trends regarding anxiety, postoperative pain and analgesic use in patients who undergo a tonsillectomy or a tonsillectomy and adenoidectomy.

NCT ID: NCT03174496 Completed - Tonsillectomy Clinical Trials

Physical Activity Tracking in Paediatric Elective Tonsillectomy

PATIPS
Start date: June 29, 2017
Phase:
Study type: Observational

This pilot study will investigate the feasibility of physical activity tracking in patients aged 4-16 years before and after elective tonsillectomy as an innovative tool in paediatric research. The participating patients will receive a wearable physical activity tracker (CE-certified) that will continuously measure the patients' physical activity before and after an elective tonsillectomy, in addition to their parents' documentation of their child's activity in a conventional diary.

NCT ID: NCT03169491 Recruiting - Clinical trials for Sleep Apnea, Obstructive

Effect of CPAP and Adenotonsillectomy in Upper Airway Volume of Children With OSAS

Start date: July 4, 2016
Phase: N/A
Study type: Interventional

Obstructive sleep apnea syndrome (OSAS) in children has high prevalence and severe complications, and its first line of treatment (adenotonsillectomy) has risk of complications. Even though the use of presurgical CPAP seems logical due to its effects in adults, it must be studied in children due to the different physiopathology and adherence. One non-invasive way of study the effect is via acoustic pharyngometry, which can measure the anatomical site of obstruction. The post-surgical anatomical changes could correlate with a persistent OSAS, which would be helpful in selecting those patients who require a post surgical sleep study. The main goal of the study is to cuantify the changes in the oropharyngeal volume via acoustic pahryngometry after CPAP use, and also the changes after adentonsillectomy in children.

NCT ID: NCT02994940 Completed - Tonsillectomy Clinical Trials

Modified Pre-operative Oral Doses Acetaminophen Versus Intravenous Acetaminophen

MODIV-APAP
Start date: August 28, 2017
Phase: Phase 4
Study type: Interventional

Acetaminophen is frequently used as an adjunct for pain management in pediatric surgical patients. The drug is available in an over the counter, inexpensive oral form as well as a considerably more expensive intravenous form. This study will compare opioid requirements and acetaminophen plasma levels post operatively for two dosing regimens to compare oral versus intravenous routes given pre operatively.

NCT ID: NCT02987985 Completed - Anesthesia Clinical Trials

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

Start date: October 15, 2017
Phase: Phase 3
Study type: Interventional

The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the post-anesthesia care unit and ward in children with sleep-disordered breathing undergoing tonsillectomy when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative respiratory depression in children with sleep-disordered breathing.

NCT ID: NCT02934191 Completed - Tonsillectomy Clinical Trials

Celecoxib After Tonsillectomy

Start date: June 2016
Phase: Phase 2
Study type: Interventional

Tonsillectomy is one of the most common pediatric surgical procedures in the United States. Postoperative pain is substantial, with typical regimens employing narcotic derivatives and acetaminophen for 1-2 weeks after surgery. Recent enthusiasm for use of ibuprofen as an alternative has been tempered by equivocal data on its relative safety in regard to risk of postoperative hemorrhage. The primary objective is to evaluate efficacy of celecoxib for pain control after tonsillectomy in children. The secondary objective is to assess safety in regard to postoperative hemorrhage and adverse events.