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Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers

Tobacco Use Disorder Clinical Trial

Official title:
Interactive Omics: Black Raspberry Metabolites and the Oral Microbiome in Smokers

Clinical Trial Summary

This randomized clinical trial studies the effects of black raspberry compounds (phytochemicals) on the bacteria in the mouth (oral microbiome) of current smokers and non-smokers. The oral microbiome protects the body from pathogenic bacteria. Smoking alters the oral microbiome and may increase the susceptibility to cancer by modulating normal host-bacteria interactions. Black raspberry phytochemicals may protect the oral microbiome of smokers and may lower their risk of developing oral cancer.

Clinical Trial Description

PRIMARY OBJECTIVES: I. Determine the effect of black raspberry phytochemicals on community dynamics within oral biofilms. II. Examine the effect of oral bacterial communities on metabolism of black raspberry phytochemicals in current and never smokers. III. Evaluate the efficacy of black raspberry phytochemicals and their metabolites in reversing the effect of smoking on oral host-microbial interactions. OUTLINE: Participants are randomized to 1 of 2 arms. ARM I: Participants receive bioactivity of black raspberry phytochemical-rich delivery vehicle (BRB nectar) orally (PO) once daily (QD) for 12 weeks. ARM II: Participants receive placebo nectar PO QD for 12 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02439255
Study type Interventional
Source Ohio State University Comprehensive Cancer Center
Contact
Status Completed
Phase N/A
Start date December 4, 2015
Completion date April 30, 2022
View Details
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