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Role of Metabolites in Nicotine Dependence (2) - 5

Tobacco Use Disorder Clinical Trial

Official title:
Role of Metabolites in Nicotine Dependence (2)

Clinical Trial Summary

The purpose of this study is to determine the effects of varying doses of cotinine on cigarette self-administration.

Clinical Trial Description

Previous studies have shown that cotinine, a metabolite of nicotine, antagonizes some of the effects of nicotine. One study showed that nicotine eliminates some of the beneficial effects of the nicotine patch in reducing withdrawal symptoms. The purpose of this study was to examine the effects of cotinine. The results generally showed no effects on self-administration of cigarettes, although higher serum nicotine levels were observed on the highest doses of cotinine compared to placebo or lower doses of cotinine. ;

Study Design

Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00000288
Study type Interventional
Source National Institute on Drug Abuse (NIDA)
Contact
Status Completed
Phase Phase 2
Start date December 1995
Completion date December 2002
View Details
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