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Tobacco Smoking clinical trials

View clinical trials related to Tobacco Smoking.

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NCT ID: NCT04167384 Completed - Smoking Clinical Trials

CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

This is a two-arm, single use, single-center, randomized, 10-sequence per arm, open-label, crossover pharmacokinetic/pharmacodynamic (PK/PD) study, designed to evaluate elements of abuse liability (AL) including subjective effects, plasma nicotine uptake, and physiological measures during and following ad libitum use of the study investigational products (IPs) by generally healthy subjects.

NCT ID: NCT04143256 Completed - Tobacco Use Clinical Trials

Evaluating Selected Constituents in the Exhaled Breath Samples

Start date: October 3, 2019
Phase: N/A
Study type: Interventional

An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional Cigarettes (Non-Menthol and Menthol Flavors)

NCT ID: NCT04132232 Recruiting - Clinical trials for Tobacco Use Disorder

Smoking Reduction In Gravid Substance Use Disorders

SIGS
Start date: February 15, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to encourage smoking cessation in women with substance use disorders by providing knowledge of expired carbon monoxide. We hypothesize that women who are provided knowledge of their expired carbon monoxide and the associated percent fetal carboxyhemoglobin will have a greater success at quitting smoking during pregnancy than women who are not provided this information. A secondary aim of the study is to correlate expired carbon monoxide throughout pregnancy with infant birth weight.

NCT ID: NCT04123041 Completed - Tobacco Smoking Clinical Trials

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

Start date: September 23, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to estimate nicotine uptake and assess subjective effects during ad libitum use sessions of 4 flavors of JUUL ENDS (also referred to as nicotine salt pod system; NSPS) products (i.e., Virginia Tobacco, Mint, Menthol and Mango) with 2 different nicotine concentrations. Subjective effects will also be assessed to gain an understanding of the user's experience during and after JUUL ENDS product use to evaluate the abuse liability of the products. The subject population will consist of healthy adult, male and female smokers, 21 to 65 years of age.

NCT ID: NCT04107779 Completed - Tobacco Use Clinical Trials

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS

Start date: September 17, 2019
Phase: N/A
Study type: Interventional

A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to using JUUL Electronic Nicotine Delivery Systems With Two Different Nicotine Concentrations

NCT ID: NCT04104152 Completed - Smoking Clinical Trials

CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting

Start date: October 7, 2019
Phase: N/A
Study type: Interventional

This study will be a single-center, randomized, controlled, open-label, parallel 2-cohort study to evaluate the puffing patterns of individuals switching from a similar usual brand (UB) Electronic Nicotine Delivery System (ENDS) product to either a 2.4% or 5% nicotine level ENDS product in healthy adult ENDS users. This study will be conducted for potential submission to the US Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as part of a Premarket Tobacco Product Application (PMTA) for an Electronic Nicotine Delivery System (ENDS), comprised of an electrical power unit and four flavor variants each with two different levels of nicotine (2.4% and 5.0%).

NCT ID: NCT04094363 Completed - Smoking Clinical Trials

CSD190202: Study to Assess Elements of Abuse Liability for Two Electronic Nicotine Delivery Systems

Start date: October 3, 2019
Phase: N/A
Study type: Interventional

This is a randomized, open-label, crossover study designed to evaluate elements of abuse liability (AL) including subjective effects, plasma nicotine uptake, and physiological measures during and following ad libitum use of the investigational products (IPs) by healthy subjects.

NCT ID: NCT04055467 Completed - Clinical trials for Tobacco Use Disorder

Brain Imaging in Tobacco Smokers During a Quit Attempt

Start date: December 16, 2019
Phase: Phase 1
Study type: Interventional

The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in α7 nicotinic acetylcholine receptor (nAChR) availability when compared to matched historical controls using positron emission tomography (PET) imaging and the radioactive ligand [18F]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6 [18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), an α7 nAChR antagonist. The study will also explore whether α7 nAChR availability influences clinically relevant measures of tobacco abstinence (e.g., withdrawal and craving, cognitive impairment), self-reported cigarettes per day, and time to relapse during an 8-day quit attempt during which smokers can receive escalating payments contingent upon providing objective evidence (breath CO and urinary cotinine) of smoking abstinence.

NCT ID: NCT04053868 Completed - Tobacco Smoking Clinical Trials

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

Start date: December 9, 2019
Phase: N/A
Study type: Interventional

This is an observational, crossover design that will examine the pharmacokinetics and pharmacodynamics of impact of smoking tobacco cigarettes or vaping the JUUL electronic cigarette.

NCT ID: NCT04038255 Recruiting - Tobacco Smoking Clinical Trials

Mindfulness Based Smoking Cessation Among Cancer Survivors

Start date: September 28, 2019
Phase: Phase 4
Study type: Interventional

This study will examine the effect of a mindfulness-based smoking cessation program among cancer survivors.