To Assess the Tissular and Plasma Kinetics of Ertapenem Clinical Trial
Goal of study:
To assess the tissular and plasma kinetics of ertapenem;
To determine the optimal dosages in the patients according to norepinephrine administration:
- to assess muscular diffusion of free form of ertapenem after administration to
mechanically ventilated patients requiring such a treatment. The patients are included
in the groups "with norepinephrine" or "without norepinephrine" according to their
hemodynamic status.
- to assess the plasma pharmacokinetics of ertapenem in mechanically ventilated patients
treated or not by norepinephrine.
Open-label, prospective study performed in a single ICU (16 beds) of a tertiary hospital
(700 beds).
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment