To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion Clinical Trial
Official title:
The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
The last couple of years it has been shown that bile acids not only acts as simple
emulsifiers of fat, but constitutes a complex metabolic integrator which not only have an
influence on fat digestion and lipid metabolism, but also modulates the energy expenditure
in (brown) adipose tissue and muscle tissue. This action is due to stimulation of the
receptor TGR5 by bile acids. Recently scientists have discovered that this receptor in
rodents is also expressed on the surface of intestinal L-cells (which normally secrets
Glucagon-Like Peptide-1 (GLP-1) in response to nutrient stimulation). The stimulation of
this receptor has shown a GLP-1 secretion from the intestinal cells which is interesting
since GLP-1 has a central role in maintaining normal glucose tolerance and thus blood sugar.
Given the above, bile acids has an important impact on intestinal GLP-1 secretion. Whether
these scientific findings can be proven in human beings is uncertain.
The primary hypothesis is that stimulating gall bladder emptying via Cholecystokinin (CCK)
in healthy subjects will result in a significant GLP-1 response. We also hypothesize that
adding orally Metformin or a sequestrant ("a bile acid binder") will further enhance this
GLP-1 response.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science