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Tissue Adhesions clinical trials

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NCT ID: NCT05545475 Recruiting - Clinical trials for Anticoagulants and Bleeding Disorders

Safety of Anticoagulant Therapy After Tissue Glue for Gastric Varices

Start date: January 1, 2022
Phase:
Study type: Observational

This study aimed to clarify the safety of anticoagulant therapy after glue injection for cirrhotic variceal bleeding patients with portal vein thrombosis.

NCT ID: NCT05475756 Recruiting - Clinical trials for Intrauterine Adhesion

Safety and Efficacy of Intrauterine Biological Barrier on Postoperative Adhesion After Hysteroscopic Adhesiolysis

Start date: February 25, 2022
Phase: N/A
Study type: Interventional

To evaluate the safety and efficacy of Intrauterine Biological Barrier developed and produced by Chengdu TopRegMed Medical Technology Co., Ltd on postoperative adhesion after Hysteroscopic Adhesiolysis.

NCT ID: NCT05462587 Recruiting - Clinical trials for Leukocyte Adhesion Deficiency

A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II

Start date: July 28, 2022
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the efficacy and safety of AVTX-803 compared to withdrawal in patients with Leukocyte Adhesion Deficiency, Type II (LAD II).

NCT ID: NCT05394662 Recruiting - Clinical trials for Intrauterine Adhesion

Safety and Effectiveness of Juveenaâ„¢ Hydrogel System Following TCGP At High-Risk for Intrauterine Adhesions

Start date: August 11, 2022
Phase: Phase 3
Study type: Interventional

This study is to determine whether intrauterine instillation of Juveena hydrogel following adhesiogenic hysteroscopic procedures (TCGP + Juveena) can safely and effectively reduce the incidence and severity of intrauterine adhesions (IUA) compared to TCGP alone.

NCT ID: NCT05381376 Recruiting - Clinical trials for Intrauterine Adhesion

Multicentre Prospective Clinical Database for the Construction of Predictive Models on Risk of Intrauterine Adhesion

Start date: January 20, 2018
Phase:
Study type: Observational

1. To establish a follow-up database for uterine adhesions and a library of biological specimens for Intrauterine Adhesion. 2. using epidemiological surveys and biological analyses to screen risk factors for the development and prognosis of Intrauterine Adhesion. 3. Predictive models based on clinical and biochemical indicators, specimen testing and hysteroscopic images are also combined with statistical analysis and machine learning algorithms to enable patients' risk stratification and prognostic assessment.

NCT ID: NCT05360186 Recruiting - Clinical trials for First Trimester Abortion

New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT

Start date: June 14, 2022
Phase: N/A
Study type: Interventional

The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester miscarriage. - To study the severity and extent of the IUA as assessed by the AFS and ESGE adhesion score in both groups of patients. - To examine the rate of complications or side effects with the NCH gel. - To assess the subsequent menstrual history and reproductive outcome in both groups of patients.

NCT ID: NCT05265559 Recruiting - Adhesion Clinical Trials

Influence of Operator Factors on Succes and Survival of Indirect Restorations

Start date: October 9, 2018
Phase:
Study type: Observational [Patient Registry]

Background: Nowadays, tissue preserving, aesthetically high-quality and sustainable dentistry is more and more becoming the standard way of treatment. To reach those standards, one of the treatment options is applying a partial indirect restoration made by glass ceramics using immediate dental sealing (IDS). Using IDS, a protocol is followed to applicate a dentin bonding agent to freshly cut dentin when it is exposed during tooth preparation for indirect restorations (inlays/onlays, crowns). The preparation made for partial restorations is minimal invasive. Glass ceramic restorations have very high survival rates (90 to 100% after five years) (Morimoto et al., 2016) and glass ceramic mimics the color and structure of the tooth very well. This kind of treatment is gaining interest and increasingly applied however little information is available on the long-term effects when multiple general practitioners apply these restorations. Objectives: The main goal of this study is to evaluate partial posterior ceramic restorations with the application of an immediate dentin sealing (IDS) performed by various practitioners. Study design and population: Twenty dental practitioners, who followed a course on making ceramic partial restorations using IDS, will be asked to include patients for this study. The dental practitioners are being asked to share their data (occlusal light photo's, impression and x-rays) of twenty-five restorations they make after having the course. Restorations of individuals with a minimum age of 18 will be included. The information from pictures and impressions will be evaluated. Items to evaluate The practitioners will be interviewed to get to know in what circumstances they do their treatment. Items that are discussed are: - using rubber dam; - using magnification by means of loupes/microscope; - scheduled time for the treatment; - number of restorations after following the course. Initial data (gathered directly after treatment) will be evaluated looking at: - surface of preparation after IDS; - size of the prepared surface; - color. Follow up data will be evaluated looking at: - tooth extraction - fracture restoration - fracture tooth - secondairy caries - de-bonding - endodontic problems Outcome: Failures (fracture, de-bonding, secondairy cariës, endodontic problems) are the main outcome measurements. Description and estimation of the load and risk for the subjects: No extra intervention is performed. The dental practitioners will provide their data (i.e. impressions, occlusal light photo's) and these will be evaluated by the researchers. Follow up data will be gathered from X-rays already made for periodical oral examination (taking the caries risk into account). Summarizing, there is no extra load or risk for the patients. Studie design Prospective practice-based research, multicenter.

NCT ID: NCT05257213 Recruiting - Clinical trials for Intrauterine Adhesion

Heparin Solution Versus Anti-adhesion Barrier Gel for Intrauterine Adhesions Prevention After Operative Hysteroscopy

Start date: February 14, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to compare the efficacy of intrauterine application of heparin solution to the use of hyaluronic acid barrier gel for the prevention of intrauterine adhesion formation after operative hysteroscopy.

NCT ID: NCT05085067 Recruiting - Clinical trials for Retained Products of Conception

The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Retained product of conception (RPOC) is defined by abnormal trophoblastic persistence or retained placenta inside the uterus cavity after a pregnancy independently of the outcome. Untreated RPOC can compromise future fertility. RPOC are generally treated surgically, either by repeated evacuation or by hysteroscopy, which exposes the uterus to additional potential trauma.The combination of trauma to the gravid uterine cavity, hypoestrogenic state at the time of the operation or immediately afterward and local infection is considered to be the pathogenic mechanism of intrauterine adhesions (IUA) , manifested clinically by menstrual abnormalities, infertility and recurrent pregnancy loss.To investigate the efficacy of auto-cross linked hyaluronic acid gel in the prevention of adhesion reformation after hysteroscopic resection of retained products of conception. After the completion of hysteroscopic resection of retained products of conception, patients will be randomized to one of the two groups by computer-generated numbers: [1] infusing auto-cross linked hyaluronic acid gel into intrauterine cavity in the experimental group; [2] no auto-cross linked hyaluronic acid gel into intrauterine cavity in the control group. Second and third look outpatient hysteroscopy will be performed 4 and 8 weeks after the initial surgery. The patients will be followed up about menstrual pattern at 3 months after the surgery.The patients will be followed up about pregancy outcome at 12 months after the surgery.

NCT ID: NCT05008315 Recruiting - Clinical trials for Postsurgical Adhesion

Effects of Soft Tissue Mobilization on Postsurgical Adhesions, Pain, Lumbopelvic Muscle Functions, Spinal Mobility, and Posture in Postpartum Women With Caesarean Section

Start date: April 8, 2023
Phase: N/A
Study type: Interventional

Postpartum women with C-section receiving deep and superficial tissue mobilization would have better improvement on pain, lumbopelvic muscle functions, spinal mobility, and posture compare to the superficial tissue mobilization and control group