Tinnitus Clinical Trial
Official title:
Transcranial Electrical and Acoustic Stimulation for Tinnitus: A Randomized Double Blind Clinical Trial
Transcranial electrical stimulation (tES) is an umbrella term for non-invasive brain stimulation using weak currents. It comprises transcranial direct current stimulation (tDCS), which is the most established and used method applying constant direct current, transcranial alternating current stimulation (tACS) with sinusoidal current in a fixed frequency, and finally transcranial random noise stimulation (tRNS), which is a subform of tACS generating a random range of low and high frequency alternating currents. A pilot study conducted by Shekhawat and colleagues in 2015 tested the effects of simultaneous electrical and acoustic stimulation. Using tDCS and bilateral broadband noise simultaneously, they found that more tinnitus patients report an improvement in tinnitus perception in comparison to conditions only using tDCS or sham. Further similar approaches very published in recent years, namely a pilot study conducted by Teissmann et al in 2014; study protocols of Rabau et al. in 2015 and Shekhawat et al. in 2015; and an experimental study by Lee et al. in 2017. Results were indicative of a superior efficacy of combined electrical and acoustic approaches, while large-scale controlled studies have not been performed. The need for extension and replication of these approaches is therefore timely. The aim behind our proposed approach, similar to the bimodal approaches above, is to couple the effects of tRNS and acoustic stimulation (AS) for better temporary tinnitus suppression and possible reversal of maladaptive neuroplasticity related to tinnitus. We aim at targeting the (bilateral) auditory cortex with tRNS as in former studies and combine it with white noise (WN) stimulation. This specific combination is novel in its nature and is building on cortical excitability following tRNS.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05963542 -
Efficacy of Online Acceptance and Commitment Therapy and Sound Therapy for Patients With Tinnitus and Insomnia
|
N/A | |
| Recruiting |
NCT04987502 -
Virtual Reality and Subjective Tinnitus
|
N/A | |
| Recruiting |
NCT04404439 -
Treatment of Tinnitus With Migraine Medications
|
Phase 4 | |
| Recruiting |
NCT05533840 -
Establishment and Application of a New Imaging System for Otology Based on Ultra-high Resolution CT
|
||
| Completed |
NCT03552302 -
Effects of Yoga Exercise on Participates With Tinnitus
|
||
| Enrolling by invitation |
NCT02617953 -
Objective Diagnosis Method and Efficacy of Repetitive Transcranial Magnetic Stimulation as a Treatment for Tinnitus
|
N/A | |
| Withdrawn |
NCT01663467 -
Efficacy of Internet and Smartphone Application-delivered Tinnitus Retraining Therapy
|
N/A | |
| Completed |
NCT02269839 -
A Feasibility Study Assessing the Effectiveness of rTMS in Tinnitus
|
N/A | |
| Completed |
NCT02974543 -
Somatosensory Stimulation to Alleviate Tinnitus
|
N/A | |
| Completed |
NCT01929837 -
Tinnitus rTMS 2013
|
N/A | |
| Completed |
NCT01857661 -
The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial
|
N/A | |
| Completed |
NCT01927991 -
Internet-based Self-help for Tinnitus: The Role of Support
|
N/A | |
| Completed |
NCT01480193 -
New Therapy for Patients With Severe Tinnitus
|
N/A | |
| Terminated |
NCT01412918 -
Inhibitor Masking Device & Sodium Channel, Voltage Gated, Type IX Alpha Subunit (SCN9) Gene Expression
|
N/A | |
| Completed |
NCT00371436 -
Progressive Intervention Program for Tinnitus Management
|
N/A | |
| Completed |
NCT00748475 -
Countering Stimulus-Induced Alpha-Desynchronization to Treat Tinnitus
|
N/A | |
| Completed |
NCT00733044 -
Cost-effectiveness of Multidisciplinary Management of Tinnitus
|
N/A | |
| Active, not recruiting |
NCT05518682 -
Assessment of Bimodal Stimulation Device Compliance and Satisfaction in Individuals With Tinnitus
|
N/A | |
| Recruiting |
NCT05212298 -
Effects of Herbal Sleep Formula on Patients With Insomnia and Tinnitus
|
N/A | |
| Completed |
NCT06025097 -
Intra-Tympanic Steroid With PRP Combination in Sensorineural Hearing Loss and Tinnitus.
|
Early Phase 1 |