Tinnitus Clinical Trial
Official title:
Safety and Effectiveness of Bilateral Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation) in the Treatment of Chronic Tinnitus
Tinnitus, i.e., the perception of sounds or noise in the absence of auditory stimuli, is a
frequent and often severely disabling symptom of different disorders of the auditory system.
There are currently no causal treatments. Using repetitive transcranial magnetic stimulation
(rTMS), we have previously demonstrated that the temporoparietal cortex is critically
involved in tinnitus perception and that tinnitus can be reduced by rTMS applied to these
cortical regions. Therefore, it is reasonable to test rTMS as a potential new treatment
strategy against tinnitus. At this stage, small pilot studies indicate some effect on
tinnitus impairment but the reduction is predominantly reported to be transient, with high
interindividual variability, and questionable clinical relevance. Moreover, the optimal
stimulation area is unclear.
Here, we use theta burst stimulation (TBS), a new rTMS paradigm for the prolonged modulation
of cortical activity. The aim of this study is to test safety and effectivity of 4 weeks of
daily bilateral TBS to two cortical areas on chronic tinnitus compared to sham-stimulation.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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