Clinical Trials Logo
  1. Home
  2. Tibia Fracture
  3. NCT04674592

Biomarkers in the Diagnosis of Acute Compartment Syndrome — BioFACTS  

Tibia Fracture Clinical Trial

Official title:
Biomarkers of Rhabdomyolysis in the Diagnosis of Acute Compartment Syndrome: Study Protocol of a Prospective Multinational, Multicentre Study in Patients With Tibial Fractures.

Clinical Trial Summary

This prospective multinational, multicentre cohort study aims to investigate the hypothesis that biomarkers of muscle cell damage can predict acute compartment syndrome in patients with tibial fractures.

Clinical Trial Description

Patients with a tibial fracture are included. P-myoglobin and P-creatine phosphokinase are analysed at 6-hourly intervals pre- and if applicable, postoperatively after surgical fixation or fasciotomy. Also, blood samples will be collected in 6 hourly intervals if acute compartment syndrome is suspected. An expert panel of senior orthopaedic surgeons will retrospectively assess study data and classify patients who had undergone fasciotomy into those with and without acute compartment syndrome. Blood samples will also be collected in patients with acute compartment syndrome without tibial fractures, to serve as a positive control group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04674592
Study type Observational
Source University Hospital, Linkoeping
Contact Jörg Schilcher, MD, PhD
Phone +46101030000
Email jorg.schilcher@liu.se
Status Recruiting
Phase
Start date April 5, 2018
Completion date December 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05000281 - Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures Phase 3
Completed NCT05613257 - Distal Targeter vs Free-hand N/A
Withdrawn NCT00240396 - Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture N/A
Withdrawn NCT04768478 - CBD for Pain Reduction and Opioid Use After Ankle and Tibia Fracture ORIF Phase 4
Completed NCT03649360 - Knee Pain After Intramedullary Nailing in the Tibia
Recruiting NCT05668182 - A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
Recruiting NCT05859451 - Effect of Tobacco Heating System (THS) on Closed Tibia Fracture Healing N/A
Not yet recruiting NCT06280417 - Unreamed Intramedullary Tibial Nailing in Treatment of Open IIIa Diaphyseal Tibial Fractures in Adults
Completed NCT03936972 - Ilizarov Frame or Uni Planar External Fixator in the Cost-conscious Era
Completed NCT06436365 - Is the Expert Nail With Poller Screws Superior to the Distal Tibial Locked Plate in the Management of Short Oblique Distal Tibial Fractures? N/A
Completed NCT03314623 - Immediate Mobilization After Plate Osteosynthesis of Proximal Tibial Fractures - A Cohort Study
Recruiting NCT05151926 - Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture N/A
Recruiting NCT01047826 - M.I.P.O. vs Intramedullary Nailing in Tibia Fractures N/A
Active, not recruiting NCT04960722 - OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone Grafting N/A
Completed NCT01691599 - Infection Rates Following Internal Fixation of Open and Closed Tibia Fractures in India
Completed NCT00793637 - Evaluation of Handling and Possible Complications Related to the Newly Developed Angular Stable Locking System (ASLS)
Completed NCT00888550 - Splinting Versus Not Splinting of the Distal Lower Extremity After Intramedullary Nailing for Tibial Fractures N/A