Comparison Between Combined Scoring of Bethesda Cytology & TIRADS

Status Completed

Clinical Trial Summary

A thyroid nodule is a discrete lesion within the thyroid gland that is radiologically distinct from the surrounding thyroid parenchyma. Most thyroid nodules are benign, with only 10% to 15% harboring cancer. This is a prospective study conducted at the department of Ear, Nose and Throat - Head and Neck Surgery (ENT-HNS) of Shree Birendra Hospital , a tertiary heath care centre of Nepal. Individuals visiting ENT-HNS outpatient department with thyroid nodules had undergone Ultrasonography (USG) of neck followed by Fine-Needle Aspiration Cytology (FNAC) from the thyroid nodules. USG was reported by Thyroid Imaging Reporting and Data System(TIRADS) and FNAC by Bethesda system. Thereafter patients were planned either for surgery either total thyroidectomy or hemithyroidectomy. Post operative histopathology was correlated with preoperative FNAC and USG reports.

Clinical Trial Description

The main objective of this prospective cohort study is to know the correlation between pre- operative Bethesda with post- operative histopathology , pre - operative TIRADS with post operative Histopathology and comparison of combined scoring of Bethesda and TIRADS with histopathology report. It is of utmost importance to deep dive into thyroid nodules workup to detect malignant nodules, as the management aspect of benign and malignant nodules has a vast difference. Thyroid ultrasonography is useful for risk stratification of nodules, and American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) classification provides recommendations for fine-needle aspiration cytology (FNAC) based on objective ultrasonography features of these nodules. To maintain uniformity in reporting system FNA sample are categorized according to the Bethesda system. Total 42 participants who met the inclusion criteria were included in the study. Statistical Analysis was done using Statistical Package for the Social Science (SPSS) version 25. Analysis was done in the form of percentage and proportion and represented as table wherever necessary. Spearman's correlation coefficient was used to evaluate the correlation between Bethesda and TIRADS. Bethesda and histopathology and TIRADS and Bethesda system. The P value was set at < 0.05 for statistical significance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06391021
Study type	Observational
Source	Tribhuvan University, Nepal
Contact
Status	Completed
Phase
Start date	June 20, 2022
Completion date	February 15, 2023

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04614389` - Utility of Contrast-Enhanced Sonography and Shear Wave Elastography	N/A
Recruiting	`NCT03295955` - Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy	N/A
Completed	`NCT04647006` - Comparison of TOETVA and Conventional Thyroidectomy	N/A
Not yet recruiting	`NCT06029946` - B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules
Recruiting	`NCT05025046` - NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules
Terminated	`NCT01320813` - Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy	N/A
Completed	`NCT00877630` - Minimal Invasiveness of Endoscopic Thyroidectomy	N/A
Completed	`NCT01964508` - microRNA in Thyroid Cancer
Completed	`NCT06306599` - Ultrasound Operator Influence on Diagnostics With AI for Thyroid Nodules - Clinial Trial	N/A
Recruiting	`NCT04730726` - In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules	N/A
Not yet recruiting	`NCT03884140` - Clinical Diagnostic Approach for Cases of Thyroid Nodules
Recruiting	`NCT02225509` - Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology	N/A
Completed	`NCT00552253` - Levothyroxine Treatment in Thyroid Benign Nodular Goiter	N/A
Not yet recruiting	`NCT03700762` - Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
Enrolling by invitation	`NCT01757834` - Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules	N/A
Completed	`NCT01292044` - The Role of Elastography in the Diagnosis of Thyroid Nodules	N/A
Completed	`NCT00858104` - Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results	Phase 4
Completed	`NCT00651625` - Reciprocating Medical Devices - a Study of a New Safety Device	N/A
Completed	`NCT05132478` - The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer	N/A
Withdrawn	`NCT03395925` - Evaluation of the Thyroid Volume After Radiofrequency Ablation of Thyroid Nodules and Recurrent Thyroid	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison Between Combined Scoring of Bethesda Cytology and TIRADS Ultrasound With Histopathology in Thyroid Nodule — TIRADS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms