Thyroid Nodule Clinical Trial
Official title:
Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
According to the grades of echogenicity to evulated thyroid nodules is a subjective process and is thus influenced by the observer's judgement. The investigators first proposed the ultrasound gray-scale ratio (UGSR) to explore its efficacy for differentiating papillary thyroid microcarcinomas from small nodular goiters.
Echogenicity is a common ultrasonic parameter to evaluate thyroid nodules. The echogenicity
of the thyroid nodule was divided into 5 grades according to gray scale. Of the five
categories, the diagnostic values of the hypoechoic and markedly hypoechoic categories have
been widely accepted for thyroid malignant nodules. However, distinguishing between
hypoechoic and markedly hypoechoic categories is a subjective process and is thus influenced
by the observer's judgement. A more objective method should be proposed to differentiate
papillary thyroid microcarcinoma(PTMC) from small nodular goiter(NG).
The investigators suspect the echo intensity of nodules could be reflected by values, as CT
values reflecting the nodule density. The investigators first proposed the ultrasound
gray-scale ratio (UGSR), namely, the ratio of lesion gray-scale value to surrounding normal
thyroid tissue, and the previous study showed UGSR can better display the relationship of
gray scale of PTMC or NG with surrounding normal thyroid tissue, and can make objective
judgment of the nodules through quantitative results.
As the absolute ultrasound grayscale value is affected by the apparatus, scan gain, dynamic
range, frequency, and operators. The investigators would collected different data acquired
from different parameters to explore their potential relations.
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