Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to demonstrate that TIR3A nodules with negative genetic test can be safely and effectively treated by radiofrequency ablation, with nodular shrinkage and improvement of clinical symptoms. Fine needle aspiration cytology is the gold standard test for differential diagnosis of thyroid nodules, but sometimes the result can be indeterminate with a risk of malignancy of 10-30%. In these cases the ablation is not indicated and many patients with benign nodules that may benefit from the procedure are not treated. All the patients enrolled must have a TIR3A cytology and negative genetic test for mutations associated with thyroid carcinoma. Before the ablation blood, evaluation of serum TSH, anti-thyroglobulin antibodies, anti-thyroid peroxidase antibodies and calcitonin levels will be performed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05765695
Study type	Interventional
Source	Istituto Auxologico Italiano
Contact	Laura Fugazzola
Phone	+390261911
Email	l.fugazzola@auxologico.it
Status	Recruiting
Phase	N/A
Start date	January 10, 2021
Completion date	January 10, 2025

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