Clinical Trials Logo
  1. Home
  2. Thyroid Nodule
  3. NCT02714946

Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules — LARA  

Thyroid Nodule Clinical Trial

Official title:
Prospective Randomized Comparative Study of the Effectiveness and Safety of Ultrasound-guided Laser and Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules

Clinical Trial Summary

The purpose of this study is to prospectively compare percutaneous radiofrequency ablation (RFA) versus percutaneous laser ablation (LA) for the treatment of solid thyroid nodules.

Clinical Trial Description

Nodular thyroid disease is a common clinical problem whose prevalence increases with age and with a more widespread use of thyroid ultrasonography. Although most thyroid nodules are benign and need only periodic monitoring, some may require treatment for associated pressure and/or cosmetic symptoms. Although thyroid surgery is the main therapeutic approach for compressive thyroid nodules, it may be associated with several drawbacks. Long-term levothyroxine suppression treatment in elderly patients with large nodular goiters is unsatisfactory because it is ineffective. Furthermore, it is associated with adverse effects on bones and the cardiovascular system. Nonsurgical, minimally invasive treatment modalities such as percutaneous laser ablation (LA) and radiofrequency ablation (RFA) have been used to treat thyroid nodules. However no studies comparing LA and RFA have been published so far.

Aims of the study

1. To evaluate whether LA and RFA cause a reduction ≥50% in the volume of thyroid nodules after 6 months and 1 year follow-up

2. To evaluate whether the features of thyroid nodules as evaluated by thyroid ultrasound, contrast-enhanced ultrasound, power-doppler and core-biopsy influence LA and RFA outcomes

3. To evaluate changes in thyroid function and thyroid autoimmunity after LA and RFA.

4. To evaluate differences between LA and RFA in terms of complications, side effects and tolerability.

Patients will be recruited, treated and followed at Santa Maria Goretti Hospital in Latina, Italy, by physicians with expertise in LA and RFA. The scientific coordinator of this study is dr. Silvia Manfrini. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02714946
Study type Interventional
Source Campus Bio-Medico University
Contact
Status Active, not recruiting
Phase N/A
Start date January 2016
Completion date January 2020
View Details
See also
  Status Clinical Trial Phase
Terminated NCT04614389 - Utility of Contrast-Enhanced Sonography and Shear Wave Elastography N/A
Recruiting NCT03295955 - Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy N/A
Completed NCT04647006 - Comparison of TOETVA and Conventional Thyroidectomy N/A
Not yet recruiting NCT06029946 - B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules
Recruiting NCT05025046 - NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules
Terminated NCT01320813 - Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy N/A
Completed NCT00877630 - Minimal Invasiveness of Endoscopic Thyroidectomy N/A
Completed NCT01964508 - microRNA in Thyroid Cancer
Completed NCT06306599 - Ultrasound Operator Influence on Diagnostics With AI for Thyroid Nodules - Clinial Trial N/A
Recruiting NCT04730726 - In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules N/A
Not yet recruiting NCT03884140 - Clinical Diagnostic Approach for Cases of Thyroid Nodules
Completed NCT04277455 - Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules N/A
Recruiting NCT02225509 - Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology N/A
Completed NCT00552253 - Levothyroxine Treatment in Thyroid Benign Nodular Goiter N/A
Not yet recruiting NCT03700762 - Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
Enrolling by invitation NCT01757834 - Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules N/A
Completed NCT01292044 - The Role of Elastography in the Diagnosis of Thyroid Nodules N/A
Completed NCT00858104 - Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Phase 4
Completed NCT00651625 - Reciprocating Medical Devices - a Study of a New Safety Device N/A
Completed NCT05132478 - The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer N/A