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NCT05626010 Clinical Trial

Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

Thyroid Disease Clinical Trial

Official title:
Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05626010
Other study ID # AAP-ibuprofen-thyroid
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date November 23, 2022
Est. completion date November 2023

Study information
Verified date November 2022
Source The Catholic University of Korea
Contact youngeun moon, MD, PhD
Phone 822-2258-6163
Email 0910momo@naver.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after thyroidectomy.

Description:

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after thyroidectomy. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed

Recruitment information / eligibility
Status Recruiting
Enrollment 62
Est. completion date November 2023
Est. primary completion date October 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 65 Years
Eligibility Inclusion Criteria: - the patients undergoing scheduled thyroidectomy - American Society of Anesthesiologists status 1 or 2 Exclusion Criteria: - refusal to be enrolled in the study - emergency surgery - hepatic or renal disease - on chronic pain medications - psychiatric disorders - pregnancy, lactation - allergy or contraindication to the study drug

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Acetaminophen
acetaminophen 1g iv dripping at end of surgery
• Ibuprofen
ibuprofen 300mg iv dripping at end of surgery

Locations
Country Name City State
Korea, Republic of Seoul St. Mary's Hospital Seoul Seocho-gu

Sponsors (1)
Lead Sponsor Collaborator
The Catholic University of Korea

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary postoperative pain the maximal postoperative pain severity using pain scale(visual analogue scale; 0 cm=no pain; 10 cm=the worst pain) during 30 minutes after surgery
Secondary pain killer requirement the incidence of the patients who require pain killer during 30 minutes after surgery
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