Thymic Epithelial Tumor Clinical Trial
Official title:
Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values
The aim of this study is to analyze aquaporins expression of thymic epithelial tumors and to compare them with apparent diffusion coefficient(ADC) from ultra-high b-values, and to test a possibility of use of ADCuh to identify the pathological type of tumor.
Magnetic resonance (MR) diffusion-weighted imaging (DWI) measures water diffusion in
biological tissue. The quantification of diffusion is described by the apparent diffusion
coefficient (ADC),which largely depends on the number and separation of barriers.Thus, ADC
can provide information regarding tissue microstructure.
According to the literature, ADC is also related to cell membrane permeability for water
molecules.It is well known that cellular water transport depends on aquaporins (AQPs).In
general,the expression of aquaporins might differ in several pathologic disorders. With
reference to this fact,we hypothesize that AQPs expression may influence ADC in thymic
epithelial tumors(TETs).Therefore,the aim of the present study is to analyze possible
associations between ADC from ultra-high b-values and AQPs expression(ADCuh) in TETs and to
use ADCuh to identify the pathological type of tumor.
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