Risk Factors of Neonatal Thrombosis

Status Completed

Clinical Trial Summary

The incidence of symptomatic thrombosis is between 2.4 and 6.8 per 1000 neonatal intensive care unit admission while it is 5.1 per 100 000 live births. Compared to adults, the anticoagulant and fibrinolytic system of newborns is significantly different. In this study, the aim is to evaluate infants with neonatal thrombosis in our unit to characterize acquired and genetic risk factors, the laboratory work-up parameters and the diagnosis approach.

Clinical Trial Description

All newborn patients diagnosed with neonatal thrombosis in our NICU between 2014 and 2019; were included in the study. Patients' data: maternal and neonatal characteristics, consanguinity, need for resuscitation, Apgar scores, diagnoses, need for mechanical ventilation, sepsis, catheter placement, treatment regimens and hospital outcomes; Laboratory findings: CBC; D-dimer levels and the performed genetic test Thrombosis diagnosis was confirmed by imaging techniques such as ultrasonography (USG), echocardiography, and magnetic resonance imaging (MRI). The genotypes: Factor V (Leiden) G1691A, prothrombin G20210A, MTHFRC677T, MTHFRA1298C, PAI-SERPINE1, Factor XIII V34L mutations ;

Study Design

Related Conditions & MeSH terms

Thrombosis

Clinical Trial Details

NCT number	NCT05367466
Study type	Observational
Source	Kirikkale University
Contact
Status	Completed
Phase
Start date	January 1, 2014
Completion date	April 10, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03826043` - THrombo-Embolic Event in Onco-hematology	N/A
Recruiting	`NCT04398628` - ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Completed	`NCT05426564` - Exploratory Assessment of the Quantra® System in Adult ECMO Patients
Not yet recruiting	`NCT05830916` - Diagnostic Role of Antiphospholipid Antibodies and Microparticles in Immune Thrombocytopenic Patients With Thrombosis
Recruiting	`NCT02972385` - Pharmacogenomics of Warfarin in Hispanics and Latinos
Completed	`NCT02917213` - Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction
Completed	`NCT02439190` - CV004-007 Thrombosis Chamber Study	Phase 1
Completed	`NCT02526628` - Thrombosis and Neurocognition in Klinefelter Syndrome
Completed	`NCT02341638` - Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986141 in Healthy Subjects	Phase 1
Completed	`NCT01855516` - Partial Thromboplastin Time After 72 Hours of Antithrombotic Prophylaxis Using Unfractionated Heparin	N/A
Unknown status	`NCT00983112` - Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery	Phase 4
Completed	`NCT00412464` - Pilot Dose Finding and Pharmacokinetic Study of Fondaparinux in Children With Thrombosis	Phase 1
Completed	`NCT00346424` - Safety and Efficacy Study of Alfimeprase in Subjects With Occluded Central Catheters	Phase 3
Completed	`NCT00479362` - Anticoagulant Therapy During Pacemaker Implantation	Phase 4
Terminated	`NCT00303420` - Alteplase for Blood Flow Restoration in Hemodialysis Catheters	Phase 4
Completed	`NCT00143715` - Oral Vitamin K for Warfarin Associated Coagulopathy	Phase 3
Completed	`NCT00039858` - Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin	Phase 4
Completed	`NCT00007410` - Genetic Architecture of Plasma T-PA and PAI-1	N/A
Completed	`NCT00000538` - Dietary Effects on Lipoproteins and Thrombogenic Activity	Phase 3
Completed	`NCT00005436` - Lupus Cohort--Thrombotic Events and Coronary Artery Disease	N/A