Ex Vivo Test of New Stroke Treatment Using Magnetic Nanorobots

Status Recruiting

Clinical Trial Summary

Tissue plasminogen activator (tPA) is the FDA approved thrombolytic drug for patients with acute ischemic stroke. While transcatheter endovascular therapy is widely accepted as an effective method for targeted blood vessels via a catheter to elicit ischemic necrosis. To improve targeting accuracy administrated tPA and avoiding collateral tissue damage, we developed a magnetic nanorobotic system to active system to active intravenous delivery of tPA for targeted thrombus removal. Here human placenta will be used as an ex vivo model for human cerebral vascular system in our ex vivo thrombolysis study. Our magnetic nanorobotic system encapsulated with tPA overcomes the limitations of passive thrombolytic therapy with tPA alone and will be a promising approach for the treatment of ischemic stroke and other thrombotic diseases

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Thrombosis

Clinical Trial Details

NCT number	NCT04644653
Study type	Observational
Source	Chinese University of Hong Kong
Contact
Status	Recruiting
Phase
Start date	September 1, 2020
Completion date	September 30, 2025

View Details

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