Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT04611191 |
| Other study ID # |
Team sports and thrombosis |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
December 30, 2024 |
| Est. completion date |
December 31, 2027 |
Study information
| Verified date |
May 2023 |
| Source |
University of Copenhagen |
| Contact |
Ylva Hellsten, Dr.Med.Sc. |
| Phone |
+4535321616 |
| Email |
yhellsten[@]nexs.ku.dk |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Cardiovascular disease, and especially myocardial infarction, is the most common cause of
death globally, and is particularly common in older individuals. Practical measures that can
reduce both the prevalence and incidence of cardiovascular disease are of great value. It is
well known that regular physical activity has a protective effect against the development of
cardiovascular diseases such as acute myocardial infarction. It has been shown that physical
activity can improve the function of the heart and blood vessels, but it is less well known
how physical activity can affect the risk of formation of dangerous blood clots, and thus the
risk of heart attack and stroke.
In a cross-sectional study it has been shown that a physically active lifestyle can reduce
the risk of blood clot formation, but experimental evidence for the importance of a period of
physical activity for the risk of blood clot formation is lacking. New methods have been set
up for measuring the coagulation profile. The analyzes are performed on a blood sample and
allow a thorough determination of platelet reactivity as well as an innovative measure of how
the microstructure of a possible blood clot would develop. In this project, these methods is
used to examine how physical activity, in the form of team sports, affects the coagulation
profile of elderly men and women.
The increasing age-related risk of cardiovascular disease is associated with endothelial
dysfunction and decrease in capillary density, and it has been shown that initiation of
capillary growth is a successful method to treat cardiovascular disease. Therefore, this
project will also investigate how a longer period of physical activity, in the form of team
sports, affects capillary density and endothelial function in men and women aged 60-70 years.
Both men and women will be recruited, as it is still unknown whether men and women respond
differently to physical activity in relation to coagulation profile, susceptibility to blood
clots and capillary density.
Description:
Cardiovascular disease, and especially myocardial infarction, is the most common cause of
death globally, and is particularly common in older individuals. Practical measures that can
reduce both the prevalence and incidence of cardiovascular disease are of great value. It is
well known that regular physical activity has a protective effect against the development of
cardiovascular diseases such as acute myocardial infarction. Therefore, the American Heart
Association also recommends ≥ 30 min. per day five days a week. It has been shown that
physical activity can improve the function of the heart and blood vessels, but it is less
well known how physical activity can affect the risk of formation of dangerous blood clots,
and thus the risk of heart attack and stroke.
In a cross-sectional study it has been shown that a physically active lifestyle can reduce
the risk of blood clot formation, but experimental evidence for the importance of a period of
physical activity for the risk of blood clot formation is lacking. New methods have been set
up for measuring the coagulation profile. The analyzes are performed on a blood sample and
allow a thorough determination of platelet reactivity as well as an innovative measure of how
the microstructure of a possible blood clot would develop. In this project, these methods is
used to examine how physical activity, in the form of team sports, affects the coagulation
profile of elderly men and women.
The increasing age-related risk of cardiovascular disease is associated with endothelial
dysfunction and decrease in capillary density, and it has been shown that initiation of
capillary growth is a successful method to treat cardiovascular disease. Therefore, this
project will also investigate how a longer period of physical activity, in the form of team
sports, affects capillary density and endothelial function in men and women aged 60-70 years.
Both men and women will be recruited, as it is still unknown whether men and women respond
differently to physical activity in relation to coagulation profile, susceptibility to blood
clots and capillary density.
Part of the novelty of this present study consist of 1) linking the clinical measurements
with data on sickness absence, disease development, etc. and with data on the underlying
mechanisms, 2) examining the short-term effect (16 weeks) and the long-term effect (up to 2
years) of physical activity, in the form of team sports in a municipality setting, on
coagulation, risk of blood clots, capillarization and endothelial function in general in the
elderly, as well as 3) investigate whether there is a difference in the aforementioned
measurements in men and women.
