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D-dimer to Improve Anticoagulation Outcome During ECMO loNg-term supporteD — DIAMOND  

Thrombosis Clinical Trial

Official title:
D-dimer to Improve Anticoagulation Management in Adult Patients Supported With Extracorporeal Membrane Oxygenation: a Prospective Cohort Study

Clinical Trial Summary

This was a prospective, cohort study.

Clinical Trial Description

Adult Patients receiving ECMO surpport in Wuhan Asia Heart Hospital were enrolled by cohort. Unfractionated heparin was used for Anticoagulation therapy, APTT or Anti-Xa activity is monitored for dose adjustment. Meanwhile, D-dimer is mornitored. If D-dimer levels continue to rise (>1.5 times previous result ), increase the dose of heparin to reach the upper limit of the treatment target; If the D-dimer levels is stable (<1.5 times previous result ) or is decreasing, the anticoagulation dose is maintained at current level (no active bleeding) or decreased (active bleeding). All patients were followed up The occurrence of endpoints during in-hospital and 30 days after discharge, including bleeding events, thrombotic events and all-cause deaths were recorded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03261284
Study type Interventional
Source Wuhan Asia Heart Hospital
Contact
Status Active, not recruiting
Phase N/A
Start date March 1, 2019
Completion date December 30, 2023
View Details
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