Thrombosis Clinical Trial
Official title:
Concentrated Citrate Locking to Reduce the Incidence of Central Venous Catheter-related Infections and Thrombosis: a Randomized Phase III Study in a Hematological Patient Population
Patients with a hematological malignancy who are undergoing intensive chemotherapy need a
central venous catheter (CVC)during their treatment. CVCs are locked with heparin when they
are not used.
The purpose of this study is to determine whether concentrated citrate locking, compared to
heparin, reduces the incidence of central venous catheter-related thrombosis and infections
in patients with hematological malignancies undergoing intensive chemotherapy.
Central venous catheter (CVC)-related thrombosis and infections are frequently occurring
complications and may cause significant morbidity in patients with hematological
malignancies. Interventions to decrease fibrin deposition have the potential to reduce
CVC-related thrombosis and infections.
At present heparin is most often used as locking solution for central venous catheters in
hematological patients despite a lack of evidence regarding the efficacy and safety.
Trisodium citrate (TSC) had been shown to be an effective antimicrobial catheter locking in
hemodialysis patients.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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