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Clinical Trial Summary

This study will evaluate the efficacy and safety of tenecteplase compared with placebo in participants with acute ischemic stroke (AIS). All participants will receive standard-of-care therapy according to AmericanHeart Association/American Stroke Association clinical guidelines (2018). To determine eligibility for randomization, all participants will undergo multimodal CT or MRI at baseline. Only participants with a vessel occlusion (ICA or MCA M1/M2) and penumbral tissue will be randomized. The primary analysis is to compare the efficacy of tenecteplase versus placebo in all participants at Day 90.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03785678
Study type Interventional
Source Genentech, Inc.
Contact
Status Completed
Phase Phase 3
Start date March 2, 2019
Completion date February 28, 2023

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