Thrombolysis Clinical Trial
Official title:
The Impact of a Helicopter Emergency Medical System on Prognosis in Stroke Patients
Stroke is a leading cause of death and disability, and 15 million people suffer a stroke
each year; one-third die and one-third are left permanently disabled. Because the risk of
stroke increases with age, it has been considered a disease of the elderly, but stroke also
occurs in middle-aged people.
Thrombolysis with tissue plasminogen activator (tPA) is the preferred choice of reperfusion
therapy of ischemic stroke if performed within 4.5 hours from symptom onset. Time to
thrombolysis is associated with improved outcome: the sooner the treatment, the less risk of
serious - and possibly permanent - damage to the brain. Unfortunately, only a small fraction
of stroke patients make it to thrombolysis within the 4.5-hour; one explanation may be
system delays including prolonged transportation.
In May 2010, the first physician-staffed Helicopter Emergency Medical Service (HEMS) was
implemented in the Eastern part of Denmark. An observational study evaluating the short-term
effects of HEMS implementation compared patients transported by conventional ground
ambulance (Ground Emergency Medical Service (GEMS)) to patients transported by HEMS.
Patients transported by helicopter had increased time to specialized care. However, both
30-day and 1-year mortality was slightly lower in patients transported by HEMS, although not
significant, as was the degree of disability at three months measured by the modified Rankin
Scale (mRS).
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03104062 -
Effect of Ticagrelor and Clopidogrel on Coronary Microcirculation in Patients With Acute Myocardial Infarction
|
N/A | |
| Completed |
NCT04925869 -
Prospective Study of Cerebrovascular Accidents (CVA) in 3 French Cities (Besançon, Cayenne and Tours)
|
||
| Recruiting |
NCT03901872 -
Contemporary Endovascular Therapies in Treatment of Acute Iliofemoral Deep Vein Thrombosis
|
||
| Completed |
NCT03785678 -
Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
|
Phase 3 | |
| Recruiting |
NCT05424978 -
Application of Standardized Green Channel Treatment System for Ischemic Stroke in Xi 'an
|
||
| Not yet recruiting |
NCT03166059 -
CaveoVasc Thrombolysis Protection System, Access Protection Study
|
N/A | |
| Recruiting |
NCT06149520 -
A Study to Learn More About How Well BAY3018250 Works and How Safe it is for People With Proximal Deep Vein Thrombosis
|
Phase 2 | |
| Recruiting |
NCT02926742 -
Submassive Pulmonary Embolism Experience With EKOS
|
N/A | |
| Recruiting |
NCT06221371 -
Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion
|
Phase 3 | |
| Active, not recruiting |
NCT01665885 -
Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)
|
Phase 2 |