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Thromboelastometry clinical trials

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NCT ID: NCT05124041 Recruiting - Cirrhosis, Liver Clinical Trials

Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy

GOODHEART-ACLF
Start date: November 15, 2021
Phase: N/A
Study type: Interventional

In this project, we plan to evaluate whether a new, rotational thromboelastometry-guided algorithm (ROTEM) to guide hemostatic resuscitation decreases the use of allogeneic blood products, the total amount of bleeding, transfusion related side effects, thromboembolic complications and costs. Its effect on each patient's post-operative hemostatic profile is also measured. We plan to enroll 140 patients having ACLF with variceal bleeding randomized into two groups: one will be treated conventionally using clinical judgement and standard coagulation tests such as prothrombin time, platelet count, etc. the other treated using a ROTEM-based algorithm. They will be followed for development of rebleeding, complications of transfusion and any signs of infection after hospitalization

NCT ID: NCT04442373 Recruiting - Clinical trials for Total Hip Replacement

Impact of Surgical Injury on Haemostatic Tests in Patients Undergoing Total Hip Replacement With Subgroup Analysis of Patients With Neoplasm

I-SIGHT-THR
Start date: January 1, 2020
Phase:
Study type: Observational

Total hip replacement (THR) is associated with extensive tissue injury and considerable blood loss that can be complicated by hyperfibrinolysis with an increased need for blood transfusion. THR in patients with cancer involving the hip joint, can reduce pain and improve or maintain the function and quality of life. However, these patients have an increased likelihood of haemostatic abnormalities, such as thrombosis or extensive blood loss. Rotational thromboelastometry is a point-of-care viscoelastic assay that can provide a measure of coagulation disorders in the above settings, and this is still under review. The objective of this prospective cohort study is to quantitate the changes in clot formation dynamics following THR with a subgroup analysis of patients with cancer.

NCT ID: NCT02652897 Recruiting - Surgery Clinical Trials

Hemostasis Alterations in Neurosurgical Patients

ABCD
Start date: May 2016
Phase:
Study type: Observational

Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.