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Thrombin clinical trials

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NCT ID: NCT04762576 Recruiting - Clinical trials for Coagulation Disorder

Thrombin in Cardiac Surgery

Start date: August 10, 2022
Phase:
Study type: Observational

Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical patients. The investigators will measure thrombin generation using our novel device and compare it to standard methods, while examining the association of thrombin parameters with bleeding and other clinical outcomes.

NCT ID: NCT04762550 Recruiting - Clinical trials for Liver Transplantation

Thrombin Generation in Liver Transplant Surgery

Start date: March 8, 2021
Phase:
Study type: Observational

This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional measures of hemostasis as well as viscoelastic tests to pinpoint specific coagulation deficits and identify potential therapeutic targets. The clinical course of patients will be followed for major bleeding and transfusion outcomes.

NCT ID: NCT04356950 Completed - COVID-19 Clinical Trials

Analysis of the Coagulopathy Developed by COVID-19 Infected Patients

COVID-TGT
Start date: April 28, 2020
Phase:
Study type: Observational

Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death. Understanding this acquired coagulopathy is a prerequisite before specific interventional studies. The study investigators aim to apply a normalized and automated thrombin generation test (TGT), developed for testing the thrombotic risk (triggered by 5 pM Tissue Factor, with a purified thrombomodulin (TM) challenge) and to study its association with survival.