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Thoracic Diseases clinical trials

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NCT ID: NCT02968550 Completed - Clinical trials for Mechanical Ventilation

Shunt Evaluation With ALPE System in Thoracic Surgery

Start date: January 2016
Phase: N/A
Study type: Observational

. The aim of this study, thus, is to evaluate shunt fraction and markers of alveolar distress during one lung ventilation (OLV) at different levels of positive end expiratory pressure (PEEP). Moreover, investigators will focus on predicting factors of high shunt levels during OLV.

NCT ID: NCT02799251 Completed - Thoracic Diseases Clinical Trials

Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections

EVALYMPH
Start date: June 2016
Phase:
Study type: Observational

Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.

NCT ID: NCT02727218 Not yet recruiting - Lung Diseases Clinical Trials

Safety of Early Removal of Chest Tubes After Thoracoscopic Lung Biopsies

Start date: May 2016
Phase: N/A
Study type: Interventional

prospective study, involves 60 patients underwent thoracoscopic surgery, the patients will be divided into two groups, the first group will undergo early chest tube removal - after three hours, the second group will have late chest tube removal according to the department's protocol. the study aims to prove the possibility and non inferiority for early chest tube removal for thoracoscopic surgeries with non complicated surgical course.

NCT ID: NCT02646813 Completed - Clinical trials for Operative, Non Cardiac, Thoracic Disease

Comparison of Intra and Extraluminal Bronchial Blocker in Adults

Start date: February 2016
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the time and ease of placement of an extra-luminal Arndt bronchial blocker versus placing it intra-luminally. An additional objective will be to assess if there are any other significant clinical differences between these two approaches to placement of the BB including overall quality of isolation, an increase in post-operatives sore throat, post-operative hoarseness, and increased incidence of needing to reposition the blocker

NCT ID: NCT02391896 Terminated - Thoracic Diseases Clinical Trials

Design and Evaluation of Mobile X-ray for Rapid and Accurate Diagnosis of Thoracic Disease

Start date: March 2015
Phase: N/A
Study type: Interventional

Computed tomography (CT) is the most accurate test for evaluating patients with thoracic disease. However, access to CT is limited due to long wait times and for the sickest patients in Hospital who cannot be transported from the ward to the CT scanner. The investigators propose to modify a standard X-ray unit to provide more detailed information of the chest such that a CT scan is not required for all patients.

NCT ID: NCT02329041 Completed - Clinical trials for Intubation Complication

Comparison of McGrath Series 5 and Airtraq Videolaryngoscope for Double-lumen Tube (DLT) Intubation

Start date: January 2015
Phase: N/A
Study type: Interventional

Previous study showed that McGrath Series 5 videolaryngoscope is an alternative tool for double-lumen tube intubation. We have compared it with traditional Macintosh laryngoscopefor double-lumen tube intubation. In this study, we will investigate its role in double-lumen tube intubation by comparison with another videolarygoscope.

NCT ID: NCT02190201 Completed - Clinical trials for Intubation Complication

Comparison of McGrath and Macintosh Laryngoscope for DLT Intubation

Start date: July 2014
Phase: Phase 4
Study type: Interventional

The investigators previous study showed that McGrath Series 5 videolaryngoscope is an alternative tool for double-lumen tube intubation. But it is not determined about the advantages and disadvantages of McGrath Series 5 videolaryngoscope for double-lumen tube intubation, compared with traditional Macintosh laryngoscope.

NCT ID: NCT02133235 Completed - Thoracic Diseases Clinical Trials

The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker

Start date: May 2014
Phase: N/A
Study type: Interventional

The need of fiberoptic bronchoscopy for placing an endobronchial blocker. Endobronchial blockers (EBB) have been presented effective and safe alternative for lung separation in vedio-assisted thoracoscopic (VATS) operations. In this study, the investigators will randomize the patients receiving VATS operation with EBB into two groups: one group will receive the conventional bronchoscopic guided EBBs placement, the other group receive two step procedure without confirmation by fiberoptic bronchoscopy.

NCT ID: NCT01860898 Completed - Lung Cancer Clinical Trials

A Phase I Study of iPS Cell Generation From Patients With COPD

Start date: September 2009
Phase: N/A
Study type: Interventional

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

NCT ID: NCT01826994 Completed - Clinical trials for Acute Coronary Syndrome

Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome

RAPIDA
Start date: September 2013
Phase: N/A
Study type: Interventional

Rationale: Thoracic complaints, possibly due to a cardiac ischemic cause are a diagnostic challenge in general practice. When an underlying ischemic cardiac condition (AMI (acute myocardial infarction), UAP (unstable angina pectoris)) is considered, referral from general practitioner (GP) to a cardiologist has to take place. However, cardiac analysis in 80% of referred patients is negative. To optimize referral decisions of GPs, new and fast diagnostics are needed. Objective: To assess the incremental diagnostic value for AMI of a novel rapid PoC H-FABP-test in addition to history taking and physical examination in patients presenting in daily general practice with possible AMI. In addition the cost-effectiveness of the test will be evaluated. Study design: Delayed type cross-sectional diagnostic study. Study population: Patients presenting to the GP with any new-onset chest complaint, at time of presentation not lasting for more than 24 hours, that is considered to be of possible cardiac origin by the GP. Intervention: Point of care Heart Type Fatty Acid Binding Protein test (PoC H-FABP-test), added to usual care. PoC H-FABP-testing, by qualitatively measuring H-FABP in one single drop of blood obtained by finger prick, is added to normal procedures of consultation and referral decision by the GP. Main study parameters / endpoints: Sensitivity, specificity, positive and negative predictive value of point of care H-FABP-testing for AMI, alone as well as part of a clinical diagnostic algorithm, in patients with thoracic complaints in general practice. All outcome measures, based on using an algorithm and/or point of care H-FABP-testing, will be compared to regular diagnostic assessment by the GP without using an algorithm and/or point of care H-FABP-testing. Therefore, incremental value of H-FABP-testing and/or a diagnostic algorithm is measured. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Individual participants will experience low risk, since study participation comprehends regular care except for an extra finger prick and possibly collection of one extra venous blood sample. For this low amount of disadvantage, the participant will experience no advantage either. However, results of the study will possibly be useful for similar patients in future.