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Clinical Trial Summary

The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.


Clinical Trial Description

The thin endometrium is detrimental to embryo implantation, probability of clinical pregnancy for an endometrial thickness ≤ 7 mm was significantly lower compared with cases with endometrial thickness > 7 mm. It has been reported the granulocyte colony stimulating factor (G-CSF) increased the endometrial thickness and pregnancy rate of infertile women with thin endometrium during IVF cycle. However, most of the researches were retrospective and small sample size, and the results were conflicted among them. GM-CSF is another member of CSF superfamily, recalling more macrophage than G-CSF, which could be more effective in local homeostasis maintain and wound repair. GM-CSF has been widely used in skin repair after burn. It was also found the GM-CSF and its receptor in endometrium. In the past year, the investigators tried GM-CSF irrigation in 21 women with thin endometrium and most of them received GM-CSF after hysteroscopic examination or slight adhesion relaxing, and the preliminary data suggested that the GM-CSF may promote the endometrial growth. Does the GM-CSF gel can improve the endometrial thickness? Therefore, this study was conducted. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04100655
Study type Interventional
Source Sir Run Run Shaw Hospital
Contact Xiaona Lin, Doctor
Phone +8657186006252
Email linna73@263.net
Status Not yet recruiting
Phase N/A
Start date October 2019
Completion date December 2020

See also
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Recruiting NCT04292886 - Thin Endometrium Undergoing Frozen-thawed Embryo Transfer N/A
Completed NCT05455151 - Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium Phase 1
Recruiting NCT06379659 - Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer Phase 1/Phase 2
Recruiting NCT06234540 - a-PRP Intrauterine Instillation in Women With Thin Endometrium N/A
Recruiting NCT03067623 - Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness Phase 2