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Thin Endometrium clinical trials

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NCT ID: NCT06379659 Recruiting - Infertility Clinical Trials

Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer

Start date: May 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this clinical trial is to see if intrauterine growth hormone infusions can help subjects reach a suitable endometrial thickness in patients who are resistant to routine hormonal therapy for embryo transfer in the In Vitro Fertilization (IVF) cycle. The primary aim of this study is to assess the effectiveness of injecting Growth hormone directly into the uterus to enhance endometrial thickness. Additionally, we aim to compare the likelihood of pregnancy between patients receiving the Growth hormone infusion and those receiving a placebo.

NCT ID: NCT06234540 Recruiting - Thin Endometrium Clinical Trials

a-PRP Intrauterine Instillation in Women With Thin Endometrium

PRP(a-PRP)
Start date: January 21, 2024
Phase: N/A
Study type: Interventional

This study sought to compare the endometrial thickness among infertile women with a history of thin endometrium together with previous cancellation from IVF/ICSI inspection of intrauterine instillation of autologous-PRP or no treatment before embryo transfer in the frozen-thaw cycles.

NCT ID: NCT05455151 Completed - Thin Endometrium Clinical Trials

Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium

Start date: October 1, 2018
Phase: Phase 1
Study type: Interventional

The investigation is devoted to the study of the effect of the introduction of autologous platelet-rich plasma (PRP) on the thickness of the endometrium. It was found that the injection of PRP and endometrial cells resuspended in PRP into the endometrium of patients with thin endometrium leads to an increase in the proliferation of endometrial cells, and as a result, to an increase in its thickness.

NCT ID: NCT04292886 Recruiting - Thin Endometrium Clinical Trials

Thin Endometrium Undergoing Frozen-thawed Embryo Transfer

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

The endometrium is essential for embryo implantation. The clinical pregnancy rate and live birth rate of patients with thin endometrium are significantly lower than those of normal endometrium. Previous studies have shown that tamoxifen has advantages for improving endometrial thickness. However, there is still a lack of evidence from randomized clinical trials comparing the efficacy between hormone replacement and Tamoxifen combined Of hormone replacement.This is a prospective, randomized placebo-controlled, double-blind clinical trial that includes 120 patients younger than 38 years old with a thin endometrium preparing for frozen embryo transfer. Participants will be randomly assigned (1: 1) into two parallel groups: estrogen replacement and tamoxifen combined with estrogen replacement.Frozen embryo resuscitation transfer cycle for thin endometrium patients。This is the first randomized controlled trial to comparing estrogen and estrogen combined with tamoxifen for endometrial improvement,The results of this study will provide evidence for the efficacy of the strategy of frozen embryo transfer cycle for thin endometrium patients.

NCT ID: NCT04100655 Not yet recruiting - Thin Endometrium Clinical Trials

The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium

Start date: October 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.

NCT ID: NCT03724617 Completed - Clinical trials for Intrauterine Adhesion

Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium

Start date: October 29, 2018
Phase: N/A
Study type: Interventional

This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness,changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.

NCT ID: NCT03067623 Recruiting - Thin Endometrium Clinical Trials

Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness

Start date: February 27, 2017
Phase: Phase 2
Study type: Interventional

The goal of this interventional study is to evaluate the increasing in endometrial thickening after the intrauterine infusion of 0,5-1 ml of autologous Platelet-Rich Plasma (PRP) and the implantation rate in women with thin endometrium undergoing Embryo-transfer, in order to propose a novel therapeutic approach for women with an endometrium < 7 mm unresponsive to standard treatments.