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Thiamin Deficiency clinical trials

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NCT ID: NCT02974257 Terminated - Cardiac Arrest Clinical Trials

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

Start date: May 1, 2017
Phase: Phase 2
Study type: Interventional

This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest. Patients who are successfully resuscitated after an in-hospital cardiac arrest and who are on mechanical ventilation in the intensive care unit will be enrolled, and will get either thiamine or placebo. Their oxygen consumption and lactate will be measured at serial time points and compared between groups. The investigators' hypothesis is that thiamine will help restore the body's ability to metabolize oxygen normally (aerobic metabolism), leading to an increase in oxygen consumption and a decrease in lactate.

NCT ID: NCT02221063 Completed - Thiamin Deficiency Clinical Trials

Thiamin Fortified Fish Sauce as a Means of Combating Infantile Beriberi in Rural Cambodia

Start date: October 2014
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether consumption of thiamin fortified fish sauce over 6 months increases the thiamin status of women to a level consistent with a low risk of infantile beriberi. The investigators hypothesize that consumption of thiamin-fortified fish sauce will increase red blood cell thiamin concentrations, an indicator of thiamin status, in women consuming thiamin-fortified fish sauce, while concentrations will not change in women consuming a placebo fish sauce that does not contain thiamin.