Thalamic Infarction Clinical Trial
Official title:
Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes : a Study in Patients With a Thalamic Infarct
The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive behavior. Thus, the project proposes to assess global cognition along with higher-order cognition integrity via sensitive behavior tasks in patients with well localized lesions (mediodorsal thalamic infarcts) compared with healthy participants.
The recruitment of patients with isolated thalamic lesion after stroke is known to be a
challenge that the investigators overcame through the expertise of neurologists within their
stroke unit.
First, they will describe the cognitive profile consecutive to a lesion of the thalamus,
assessed with standardized neuropsychological tests.
Second, and more specifically, they will study performances at experimental tasks focusing on
higher-order cognition (decision-making, updating, interference managing, multitasking).
They will use the automatic localization method already performed : the lesions will be
manually segmented from T1 morphologic sequences, and then normalized in a template. Finally
a numerical atlas of thalamus will be applied on the lesions, determining the injured
substructure and the lesion volume.
Besides, this method will be compared with new high resolution thalamus-centered anatomical
sequences allowing direct and individual identification of the involved thalamic nucleus.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04921683 -
The Use of LIFUP in Chronic Disorders of Consciousness
|
N/A |