Surgical Management and Outcome of Tethered Cord Syndrome

Tethered Cord Syndrome Clinical Trial

Official title:

Tethered Cord Syndrome: Surgical Management and Outcome

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05579795
• Other study ID #: Tethered Cord Syndrome
• Status: Not yet recruiting
• Start date: November 2, 2022
• Est. completion date: December 2, 2024

Study information

• Verified date: November 2022
• Source: Assiut University
• Contact: Amr Gamal Hussein, GP
• Phone: 01067651618
• Email: amrgamalz[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to assess surgical management and outcome of Tethered cord syndrome

Description:

Tethered cord syndrome (TCS) is a developmental abnormality of the neuroaxis which is usually diagnosed in childhood. The actual tethering has been attributed to a variety of pathologic entities, including a thickened tight filum terminale , intradural lipomas with or without a connecting extradural component, intradural fibrous adhesions, diastematomyelia, and adherence of the neural placode following previous closure of a myelomeningocele. However, sufficient differences in the mode of onset, clinical manifestations, and outcome exist between pediatric and adolescent patients with tethered cord to warrant a more detailed analysis of the adult syndrome. The most problematic technical consideration in surgery for the release of the tethered cord is how to preserve functioning neural elements and rebuild the dural sac to avoid CSF leak. The purpose of this study is to review causes of Tethered cord, clinical presentation, diagnostic tools, treatment options and outcome in school-aged children, adolescents, and young adults with Tethered cord.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 35
• Est. completion date: December 2, 2024
• Est. primary completion date: November 2, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 1 Year to 16 Years

Eligibility

Inclusion Criteria:

• Patients with Tethered cord syndrome presenting at our institute

• Patients with spinal dysraphism

• Lipomyelomeningocele with Tethered cord

• patients presented with neurological deficit after lipomyelomeningocele repair due to Tethered cord

• patients presented with neurological deficit after myelomeningocele repair due to Tethered cord

• Diastematomyelia with Tethered cord - Tethered cord due to filum terminale.

• Tethered cord due to fibrous adhesions

Exclusion Criteria:

• Asymptomatic Patients with Tethered cord discovered accidentally

Related Conditions & MeSH terms

• Neural Tube Defects
• Syndrome
• Tethered Cord Syndrome

Intervention

Procedure:
• Detethering of the spinal cord
Release of the tethered spinal cord

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Motor power	Outcome of Detethering of the Tethered spinal cord according to Motor power of the lower limbs 5 grades 0: No visible muscle contraction; Visible muscle contraction with no or trace movement; Limb movement, but not against gravity; Movement against gravity but not resistance; Movement against at least some resistance supplied by the examiner; Full strength	Two years
Primary	Sensations	Outcome of Detethering of the Tethered spinal cord according to the sensations of lower limbs , is there decreased sensations of lower limbs and if improved or not	Two years
Primary	Sphincter's function	Outcome of Detethering of the Tethered spinal cord according to is there urinary incontinence or stool incontinence and if improved or not	Two years