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Testicular Diseases clinical trials

View clinical trials related to Testicular Diseases.

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NCT ID: NCT05146466 Completed - Testicular Diseases Clinical Trials

Enhancing Men's Awareness of Testicular Diseases (E-MAT): A Feasibility Trial

E-MAT
Start date: March 15, 2022
Phase: N/A
Study type: Interventional

Hypothesis: Is it feasible to conduct a definitive trial to test the effect of E-MATVR compared to E-MATE on primary and secondary outcomes among Gaelic Athletic Association (GAA) members (players and coaches)? The overall aim of this study is to examine the feasibility of conducting a definitive trial to test the effect of an educational intervention to Enhance Men's Awareness of Testicular diseases using Virtual Reality (E-MATVR) among male GAA members. The effect of E-MATVR will be compared to E-MATE (control) which involves using the same information as E-MATVR delivered as plain text (e.g., PDF) with still images from E-MATVR.

NCT ID: NCT03403777 Completed - Neoplasms Clinical Trials

Avelumab in Refractory Testicular Germ Cell Cancer.

Start date: November 15, 2017
Phase: Phase 2
Study type: Interventional

This is a proof-of-concept study to define efficacy of AVELUMAB in patients with multiple relapsed/refractory germ cell tumors (GCTs). Data suggest that PD-L1 is overexpressed in TGCTs, and PD-L1 expression is significantly higher in GCTs in comparison to normal testicular tissue.Patients with low PD-L1 expression had significantly better progression-free survival (hazard ratio [HR] = 0.40, 95% CI (0.16 - 1.01, p = 0.008) and overall survival (HR = 0.43, 95% CI (0.15 - 1.23, p = 0.040) compared to patients with high PD-L1 expression. These data suggest that PD-1/PD-L1 pathway could be a novel therapeutic target in TGCTs and that there is strong rationale to inhibit PD-1/PD-L1 signaling in GCTs.

NCT ID: NCT00012480 Completed - Male Infertility Clinical Trials

Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm

Start date: August 2002
Phase: N/A
Study type: Observational

Our data indicate that environmental exposure to the heavy metal lead are more widespread than currently appreciated and that such exposures are associated with the production of human male subfertility. Lead's effects are observed in male partners of infertile couples attending an IVF clinical, in men acting as semen donors in an artificial insemination program and in men representative of the general public. Our goal is to identify the mechanism(s) underlying lead's anti-fertility action.