Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

Test Meal Clinical Trial

— FruPP  

Official title:

Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03195062
• Other study ID #: 2016-01828
• Status: Completed
• Phase: N/A
• Start date: March 23, 2017
• Est. completion date: August 31, 2018

Study information

• Verified date: October 2018
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.

The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: August 31, 2018
• Est. primary completion date: June 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Aged from 18 to 40 years

• Body Mass Index of 18.5 to 25 kg/m²

• Sex male of female

Exclusion Criteria:

• Fructose intolerance

• Antidiabetic and hypolipemic drugs

• Alcohol consumption >10g/day

• Severe eating disorders

• Severe psychological problems

• Vegetarian diet or other specific diet

• Consumption of illicit substances

• Pregnancy

• Weight gain or weight loss > 3 kg in the last 3 months

Related Conditions & MeSH terms

• Test Meal

Intervention

Other:
• Test meal
Liquid test meal (fructose+glucose)

Locations

Country	Name	City	State
Switzerland	University of Lausanne	Lausanne

Sponsors (1)

Lead Sponsor	Collaborator
University of Lausanne

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.	Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min.	The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.