Clinical Trials Logo
  1. Home
  2. Telomere Shortening
  3. NCT04211714

Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure

Bone Marrow Failure Clinical Trial

Official title:
A Phase I/II Study to Evaluate the Safety and Tolerability of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure

Clinical Trial Summary

This is a Phase I/II, open label, single center study to assess the safety and tolerability of EXG34217 in bone marrow failure patients with telomere biology disorders.

Clinical Trial Description

This is a Phase I/II, open label study in up to 12 subjects with telomere biology disorders with bone marrow failure. The study is open to all participants regardless of gender or ethnicity. Subjects who are enrolled but not evaluable will be replaced. Subjects will sign a consent form prior to any study related procedure and will complete baseline screening assessments. Subjects for this study will not require any preparative regimen such as chemotherapy or radiation. The study will be conducted in three parts - Peripheral blood mononuclear cells (PBMNCs) collection; mobilization and apheresis, - Ex vivo cell processing - Processed cell infusion and post-infusion safety monitoring, - Follow-up (Week 2, 3,4,5, Months 1, 2,3,4,5,6,9 and 12) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04211714
Study type Interventional
Source Elixirgen Therapeutics, Inc.
Contact Martine Francis
Phone 301-343-8894
Email martine@mafinc.com
Status Recruiting
Phase Phase 1
Start date April 8, 2021
Completion date April 8, 2027
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04638517 - The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis Phase 2
Completed NCT02844478 - Stress-Busting Program and QoL, Bio-markers of Immunity/Stress and Cellular Aging N/A
Completed NCT04763525 - Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals. N/A
Active, not recruiting NCT02299245 - Rosuvastatin Effect on Telomere-telomerase System in ACS Phase 4
Not yet recruiting NCT03710356 - Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy Phase 1/Phase 2
Recruiting NCT05508321 - Nasal Brushing for the Diagnosis and Understanding of Telomeropathies N/A
Completed NCT03982589 - Telomere Length in Relation to Acute Stress Response in Critical Care Patients
Not yet recruiting NCT05978921 - Physical Exercise in Patients With Schizophrenia N/A
Terminated NCT05715372 - Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy N/A
Active, not recruiting NCT03286699 - Lifestyle Change for Better Health N/A
Not yet recruiting NCT05598359 - TA-65 and Aging Associated Microvascular Dysfunction N/A
Recruiting NCT06056375 - Biological and Behavioral Outcomes of Community Nature Walks Phase 1
Completed NCT02055456 - Nandrolone Decanoate in the Treatment of Telomeropathies Phase 1/Phase 2
Completed NCT03459053 - CBART: The Reduction of Psychological and Physiological Stress in Women Undergoing IVF N/A