Clinical Trials Logo
  1. Home
  2. TBI (Traumatic Brain Injury)
  3. NCT06195345

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1) — ICHOR 1  

Hemodynamic Instability Clinical Trial

Official title:
Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

Clinical Trial Summary

This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.

Clinical Trial Description

This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study. Treatment: Those who meet eligibility criteria, and who undergo the informed consent, will have their MRI extended by up to 7.5 minutes for up to 5 times. Standard-of-care anesthesia safety, dose and monitoring will not be changed. During their MRI, the additional images acquired will teach us about cerebral blood flow and cerebral venous oxygenation. Participants will also have non-invasive monitoring of their hematocrit immediately following the exam. Safety Assessment: The experiment will occur in the standard-of-care clinical MRI environment. All patient safety and monitoring will remain in place. Throughout the induction, maintenance and recovery from anesthesia, all procedures will occur in the standard of care environment and will be overseen by trained clinical personnel. Efficacy Assessment: Structural, and/or cerebral blood flow and/or metabolism MRIs will be collected from all subjects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06195345
Study type Observational
Source Children's Hospital Los Angeles
Contact Hannah E Wiseman, MPH
Phone 323-361-3963
Email hwiseman@chla.usc.edu
Status Recruiting
Phase
Start date November 1, 2018
Completion date November 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT03653910 - Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope N/A
Completed NCT06000098 - Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Recruiting NCT02565251 - Volemic Resuscitation in Sepsis and Septic Shock N/A
Terminated NCT02365688 - Hemodynamic Response During Goal Directed Fluid Therapy in the OR N/A
Completed NCT01559675 - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery N/A
Completed NCT01605279 - Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns Phase 2
Recruiting NCT04010058 - Postoperative Continuous Non-invasive Haemodynamic Monitoring on the Ward N/A
Completed NCT06268275 - Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy N/A
Recruiting NCT04926220 - Dynamic Estimation of Cardiac Output in the Operating Room
Not yet recruiting NCT05003011 - Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
Completed NCT03599440 - Effect of Extended Infusion Lines on Pulse Contour-based Measurements
Completed NCT05035485 - Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia N/A
Not yet recruiting NCT04227821 - Hemodynamic Optimalization in Pediatric Patients
Completed NCT05481047 - Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery N/A
Completed NCT06158165 - Evaluating The Cardiovascular Effects of Tourniquet Application
Not yet recruiting NCT04076709 - Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery Phase 4
Completed NCT04089098 - VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
Not yet recruiting NCT03828032 - Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients. N/A
Recruiting NCT05570682 - Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy N/A
Completed NCT04574908 - A Pilot Trial of Continuous Portable Postoperative Hemodynamic And Saturation Monitoring On Hospital Wards N/A