TBI (Traumatic Brain Injury) Clinical Trial
Official title:
A Multi-Center Study of Near-Infrared Spectroscopy (NIRS) for Hematoma Detection
The purposes of this study are:
1. To determine the sensitivity and specificity of the Near-Infrared Spectroscopy (NIRS)
measurements for identifying intracranial hematomas due to trauma.
2. To determine the reproducibility of the Near-Infrared Spectroscopy (NIRS) measurements
with different operators and at different centers
The principle used in identifying intracranial hematomas with Near-infrared spectroscopy
(NIRS) is that extravascular blood absorbs Near-infrared light more than intravascular blood
since there is a greater (usually 10-fold greater) concentration of hemoglobin in the acute
hematoma then in the brain tissue where blood is contained within vessels. Therefore, the
absorbance of Near-infrared light is greater (and therefore the reflected light less) on the
side of the brain containing a hematoma, than on the uninjured side.
The NIRS sensor is placed successively in the left and right frontal, temporal, parietal, and
occipital areas of the head and the absorbance of light at selected wavelengths is recorded.
The difference in optical density in the different areas is calculated.
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