Clinical Trials Logo
  1. Home
  2. Takotsubo Cardiomyopathy
  3. NCT06323811
  4. Details
NCT06323811 Clinical Trial

Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics

Takotsubo Cardiomyopathy Clinical Trial

— COPE-CMR  

Official title:
Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA, Tako-Tsubo, SCAD, Myocarditis and NSTEMI in the Acute Phase and Post Convalescence

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06323811
Other study ID # COPE CMR
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date June 15, 2023
Est. completion date December 31, 2025

Study information
Verified date March 2024
Source University of Zurich
Contact Robert Manka, Prof., MD
Phone +41442551251
Email robert.manka@usz.ch
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR. The present study aims to: - assess the microvascular function with a novel quantitative 3D myocardial perfusion imaging approach in the acute phase and post-convalescence - refine the role and diagnostic potential of advanced quantitative CMR imaging - assess the potential prognostic significance of microvascular dysfunction and epicardial adipose tissue on cardiovascular outcomes Participants will undergo advanced CMR imaging in the acute setting (within 10 days after event) and post convalescence (after 3 months).

Description:

Advanced CMR includes a novel free-breathing motion-informed locally low-rank quantitative 3D myocardial perfusion imaging. Perfusion imaging will be compared with 3D late gadolinium enhancement (LGE) imaging. A cine Dixon sequence is performed for the assessment of epicardial adipose tissue (EAT).

Recruitment information / eligibility
Status Recruiting
Enrollment 75
Est. completion date December 31, 2025
Est. primary completion date June 30, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - acute presentation with signs/symptoms of acute coronary syndrome or myocarditis - elevated cardiac biomarkers - no signficant coronary artery disease on coronary angiogram or coronary CT Exclusion Criteria: - pacemaker/other devices or claustrophobia - severe asthma, chronic obstructive lung or kidney disease - acute pulmonary embolism - arrhythmia on ECG - moderate to severe valvular disease

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• CMR
Advanced CMR imaging including a novel quantitative free-breathing 3D perfusion sequence, 3D LGE imaging and a cine Dixon sequence

Locations
Country Name City State
Switzerland University Hospital Zurich Zürich

Sponsors (2)
Lead Sponsor Collaborator
University of Zurich ETH Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Myocardial perfusion reserve index comparison of microvascular function in the acute phase versus post convalescence within 10 days and after 3 months after index event
Secondary epicardial adipose tissue (EAT) the amount of epicardial adipose tissue 4 months (measured either at first or second CMR)
Secondary cardiovascular events rate of cardiovascular death, myocardial infarction, recurrence of MINOCA, myocarditis, takotsubo cardiomyopathy, SCAD 5 years
See also
  Status Clinical Trial Phase
Recruiting NCT04325321 - The Broken Heart Study II (BHS-II) N/A
Recruiting NCT03663348 - Registry of Patients With Takotsubo Syndrome
Recruiting NCT04695587 - The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome
Completed NCT05530135 - Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy N/A
Not yet recruiting NCT05946772 - Cyclosporine In Takotsubo Syndrome Phase 2
Completed NCT02240056 - Brain fMRT In Takotsubo Cardiomyopathy
Completed NCT02307214 - Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology N/A
Recruiting NCT05977049 - Psychosocial Support for Patients With Takotsubo Syndrome N/A
Recruiting NCT06277297 - Prognotic Role of CMR in Takotsubo Syndrome
Completed NCT03787810 - Left Ventricular Dysfunction in Critically Ill Patients
Active, not recruiting NCT00123695 - Serial Echocardiography After Subarachnoid Hemorrhage N/A
Recruiting NCT05793008 - Characterization of priMary And sEcondary STress Related takOtsubo N/A
Recruiting NCT04513054 - Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy N/A
Completed NCT04425785 - Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study N/A
Recruiting NCT02361073 - The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy N/A
Recruiting NCT03299569 - Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland
Recruiting NCT01947621 - International Takotsubo Registry (InterTAK Registry) N/A
Completed NCT04684004 - Hyperglycemia in Patients With Takotsubo Syndrome
Completed NCT02759341 - Brain-heart Interactions in Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: N/A
Completed NCT02659878 - Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage