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A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis

Systemic Sclerosis Clinical Trial

Official title:
A Phase 1/2, Open-Label, Multicentre Study of KYV 101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis (KYSA-5)

Clinical Trial Summary

A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects with Systemic Sclerosis

Clinical Trial Description

SSc is an immune-mediated rheumatic disease that is characterized by fibrosis of the skin and internal organs and vasculopathy. B-cells play a role in SSc, and the disease is characterized by the presence of autoantibodies such as anti-Scl-70 and anti-RNAP III antibodies. CD19-targeted chimeric antigen receptor (CAR) T-cells harness the ability of cytotoxic T-cells to directly and specifically lyse target cells to effectively deplete B-cells in the circulation and in lymphoid and potentially non-lymphoid tissues. KYV-101, a fully human anti-CD19 CAR T-cell therapy, will be investigated in adult subjects with systemic sclerosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06400303
Study type Interventional
Source Kyverna Therapeutics
Contact Kyverna Therapeutics, Inc.
Phone 510-925-2484
Email Clinicaltrials@kyvernatx.com
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date May 2024
Completion date March 2027
View Details
See also
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