Systemic Sclerosis Clinical Trial
Official title:
Professional and Personal Toxic Exposure in Systemic Sclerosis : Type, Intensity and Probability of Exposition
Systemic Sclerosis (SSc) is an inflammatory chronic disease that can lead to structural damage and handicap. The SSc physiopathology is multifactorial, including genetic and environmental risk factors. The identification of environmental factors implication is crucial to understand the SSc mechanism, and improves the diagnosis and the treatment of the disease.
Studies show that the risk associated with high cumulative exposure to silica and organic
solvents appears to be strongly increased in SSc. Moreover, exposure to silica is associated
with a specific type of SSc phenotype with a worse prognosis. However, the type, intensity
and probability of these expositions are unknown.
The aim of the study is to precisely determine type, intensity and probability of toxic
substances exposition in Systemic Sclerosis patients through an auto-questionnaire and
integration of these data in a computer matrix.
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