Systemic Sclerosis Clinical Trial
Official title:
A Phase Ⅱ Pilot-Study With Sirolimus for the Treatment of Systemic Sclerosis
The purpose of the study is to examine the safety and effectiveness of sirolimus treatment
for people with systemic sclerosis.
The investigators perform a multi-centre, double-blind pilot trial with sirolimus in SSc.The
investigators evaluate the effectiveness and safeness of sirolimus for Systemic Sclerosis by
randomized controlled study (sirolimus 2mg/d (N = 36) versus placebo group (N = 36)).
Each SSc patients (n=72) received sirolimus or placebo (active group: placebo group =1:1,
2mg/day， oral administration, (SIR 2mg, po., Qd) .
The end points were the changement of modified RSS and the adverse events or severe adverse
events onset.
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