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Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH) — VOC-PAH  

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Volatile Organic Compounds as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension

Clinical Trial Summary

Aim: to investigate the role of inflammation and auto-immunity in pulmonary arterial hypertension by using the profile of volatile organic compounds. Hypothesis: first, the investigators hypothesize that at time of diagnosis the VOC profiles will discriminate patients with PAH-CTD and idiopathic PAH (IPAH) from patients with systemic sclerosis or systemic lupus erythematosus (CTD) without PAH, supporting the contention that there is a overlapping inflammatory and auto-immune pathway in PAH. During follow-up, the investigators will measure the VOC profiles of patients in all three groups who will be treated according standard clinical care. The hypothesis is that VOC profiles are affected by therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03819777
Study type Observational
Source Maastricht University Medical Center
Contact Judith Potjewijd, MD
Phone +31 (0) 433871198
Email pah.uitademingslucht.int@mumc.nl
Status Recruiting
Phase
Start date March 1, 2018
Completion date January 31, 2023
View Details
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