Endothelial Dysfunction Clinical Trial
Official title:
Subclinical Cardiovascular Health Benefits of Interventions to Reduce Exposure to Combustion-Derived Particulate Air Pollution
This study is focused on the effects of HEPA filtration to reduce exposures to
combustion-derived air pollution (CDAP). Specifically, the study will evaluate the health
benefits of HEPA filters and compare the cardiovascular toxicity of two major sources of
CDAP, specifically traffic and residential wood combustion.
Specifically, the purpose of this study is to evaluate the ability of portable high
efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and air pollution
indoors and to improve subclinical indicators of microvascular function and systemic
inflammation among healthy adult participants.
The investigators hypothesize that HEPA filter use will help decrease indoor concentrations
of CDAP thereby helping to mitigate the associated cardiovascular risks.
To address knowledge gaps about health risks of specific pollution sources and to provide
new evidence on the health benefits of air pollution interventions, the objectives of this
study are: 1) quantify the relationship between low-level exposures to combustion-derived PM
air pollution and subclinical indicators of cardiovascular disease risk; and 2) compare the
relative impact of HEPA filtration for two major PM sources (traffic and residential wood
combustion) on these indicators.
The use of HEPA filters may help to mitigate cardiovascular risks factors caused by
combustion-derived air pollution (CDAP), (specifically woodstove and traffic emissions). We
hypothesize that HEPA filter use and improved woodstove technology will help decrease indoor
occurrences of CDAP. This project will help address knowledge gaps in CDAP-related health
risks and benefits of interventions. Specific objectives include establishing a relationship
between exposure to CDAP and biomarkers of cardiovascular risk and evaluating the impact of
HEPA filter use towards improved indoor air quality and health indicators.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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