Systemic Inflammation Clinical Trial
— HIPWOODSOfficial title:
Health Effects Related to Exposure to Particle Pollution From Woodburning
The study intends to focus on health effects and symptoms related to particle exposure from
wood burning stoves
The objective is to determine whether moderate exposure to particles from wood smoke in a
real life situation causes an systemic inflammatory response in peripheral blood or in lower
airways. 24 healthy subjects (normal healthy subjects and mild asthmatics to study the
asthmatic response) is selected for the study. A randomized double blind crossover procedure
will be followed with a PM exposure concentration of 200ug/m3, 400ug/m3 or clean air as the
control exposure. Exposure will take place in a climate chamber using wood burning in an
appropriate wood stove.
Status | Completed |
Enrollment | 20 |
Est. completion date | November 2009 |
Est. primary completion date | June 2008 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 64 Years |
Eligibility |
Inclusion Criteria: - Twenty-four, non-smoking atopic volunteers with normal lung function and bronchial reactivity are recruited for the study. Atopy is determined by skin-prick testing to common aeroallergens. Exclusion Criteria: - Smokers, pregnant women and other subjects with current or previous diseases, which could involve a risk for the subject or possibly influence the outcome measurements, will be excluded from the study. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
Country | Name | City | State |
---|---|---|---|
Denmark | Institute of Environmental and Occupational Medicine , Institute of Public Health , The Faculty of Health Sciences | Aarhus C |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus | Aarhus University Hospital, University of Copenhagen |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Different Inflammation Biomarkers | Baseline and follow up measurement after exposure 0 hours post, a 6 hours post and 20 hours post. | Yes | |
Secondary | Baseline and follow up measurements are: spirometry, exhaled breath condensate, nasal lavage, nasal patency, blood sampling and symptoms. | Baseline and follow up measurement after exposure 0 hours post, a 6 hours post and 20 hours post. | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00229034 -
Effect of APC and Epo on the Inflammatory Response During Sepsis
|
N/A | |
Completed |
NCT02051634 -
Papaya Study ID:20140628
|
Phase 1 | |
Not yet recruiting |
NCT06072066 -
Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
|
N/A | |
Recruiting |
NCT04769687 -
Symbiotics and Systemic Inflammation in Chronic Kidney Disease
|
Phase 2 | |
Completed |
NCT01488500 -
Woodsmoke Exposure and Cardiovascular Function
|
N/A | |
Completed |
NCT01570062 -
Cardiovascular Effects of Aerosols in Residences Study
|
Phase 2 | |
Completed |
NCT01256957 -
Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health
|
N/A | |
Recruiting |
NCT03050476 -
Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase
|
Phase 2/Phase 3 | |
Active, not recruiting |
NCT03442348 -
Omega 3 and Fibre Intervention Study to Improve Metabolic Health
|
N/A | |
Recruiting |
NCT03510442 -
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
|
||
Withdrawn |
NCT01092572 -
Statins To Treat Adult Cystic Fibrosis
|
Phase 1/Phase 2 | |
Enrolling by invitation |
NCT06322641 -
A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
|
||
Completed |
NCT04314739 -
The Effects of Resveratrol Supplementation on Inflammation and Cognitive Performance in Healthy Adults
|
N/A | |
Completed |
NCT04728165 -
Anti-Inflammatory Effects of Time-Restricted Feeding
|
||
Completed |
NCT03812627 -
Study of Systemic Impact of Trace Elements Release by Implantable Medical Devices. Identification of Biomarkers of Systemic Inflammation
|
N/A | |
Completed |
NCT00780520 -
The Effect of Glutamine on Systemic Inflammation During Human Experimental Endotoxemia
|
N/A | |
Recruiting |
NCT03935061 -
Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder
|
N/A | |
Enrolling by invitation |
NCT05350774 -
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
|
Phase 2 | |
Completed |
NCT04161378 -
Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
|
||
Completed |
NCT03448094 -
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
|
N/A |