Global Syphilis Sequencing

Status Completed

Clinical Trial Summary

Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab. In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Syphilis

Clinical Trial Details

NCT number	NCT03709862
Study type	Observational
Source	London School of Hygiene and Tropical Medicine
Contact
Status	Completed
Phase
Start date	October 8, 2018
Completion date	February 28, 2022

View Details

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