Global Syphilis Sequencing

Status Completed

Clinical Trial Summary

Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab. In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Syphilis

Clinical Trial Details

NCT number	NCT03709862
Study type	Observational
Source	London School of Hygiene and Tropical Medicine
Contact
Status	Completed
Phase
Start date	October 8, 2018
Completion date	February 28, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03660488` - Cefixime for Alternative Syphilis Treatment	Phase 2
Recruiting	`NCT05548426` - Linezolid for Syphilis Pilot Study	Phase 2
Not yet recruiting	`NCT05951751` - The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)	N/A
Completed	`NCT02191527` - Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique	N/A
Completed	`NCT01439503` - Safer Sex Program for Young African-American Men	Phase 2
Completed	`NCT02257658` - Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM	N/A
Terminated	`NCT01540227` - Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis.
Completed	`NCT02611765` - Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study	Phase 4
Completed	`NCT03637660` - Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection	Phase 4
Active, not recruiting	`NCT03310424` - Transcriptomic and Next Generation Sequencing Approaches to Infection With Treponema Pallidum
Completed	`NCT00207506` - Lay Health Advisors for Sexually Transmitted Disease Prevention	Phase 1/Phase 2
Completed	`NCT00213018` - Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission	Phase 2
Recruiting	`NCT06059443` - mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention	N/A
Completed	`NCT04480749` - Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST)	Phase 4
Not yet recruiting	`NCT06058286` - MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia	N/A
Active, not recruiting	`NCT03980223` - Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men	Phase 4
Completed	`NCT01465607` - Implementation of an Efficacious Intervention for High Risk Women in Mexico	N/A
Completed	`NCT00553111` - Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission	N/A
Active, not recruiting	`NCT06367621` - Retrospective Study of iStatis Syphilis Ab Test (POC)
Completed	`NCT02445846` - Dual Rapid HIV & Syphilis Tests in Zambia	N/A